SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yhm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		4 / 8 LEU A  52
HIS A  59
ILE A 160
ILE A 163
 None
 0.84A 2bu8A-2yhmA:
undetectable		 2bu8A-2yhmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 11 VAL A  95
ILE A  33
ALA A 117
SER A 118
ASP A  78
 None
 1.45A 2iyfA-2yhmA:
undetectable		 2iyfA-2yhmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		3 / 3 HIS A 216
ILE A  33
LEU A  68
 None
 0.72A 2kceA-2yhmA:
undetectable		 2kceA-2yhmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 12 PHE A 111
SER A 131
HIS A 151
LEU A  51
LEU A 119
 None
 1.50A 3adsA-2yhmA:
undetectable		 3adsA-2yhmA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 10 ALA A 206
ILE A 163
ILE A 159
LEU A  52
ILE A 160
 None
 1.27A 4dtaA-2yhmA:
undetectable		 4dtaA-2yhmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 2yhm NUCLEOPROTEIN
(Human
orthopneumovirus) 		5 / 12 MET A 257
ALA A 264
LEU A 325
VAL A 277
ASP A 345
 None
 1.42A 5vlmC-2yhmA:
3.4		 5vlmC-2yhmA:
22.04