SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2yho E3 UBIQUITIN-PROTEIN
LIGASE MYLIP
(Homo
sapiens) 		4 / 8 CYH A 421
VAL A 420
CYH A 402
GLY A 403
 ZN  A1002 (-2.3A)
ZN  A1002 ( 4.9A)
ZN  A1002 (-2.3A)
None
 0.99A 1ekjA-2yhoA:
undetectable
1ekjB-2yhoA:
undetectable		 1ekjA-2yhoA:
18.13
1ekjB-2yhoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2yho E3 UBIQUITIN-PROTEIN
LIGASE MYLIP
(Homo
sapiens) 		5 / 12 ALA A 412
LEU A 415
VAL A 425
GLY A 403
LEU A 433
 None
 1.24A 5x24A-2yhoA:
undetectable		 5x24A-2yhoA:
10.83