SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 4 PHE A 662
ASP A 665
PHE A 361
VAL A 619
 None
 1.41A 1w0fA-2yiaA:
0.0		 1w0fA-2yiaA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 8 SER A 269
VAL A 265
LEU A 266
PRO A  96
 None
 0.93A 2ddwA-2yiaA:
undetectable		 2ddwA-2yiaA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 10 ARG A 639
GLY A 651
GLY A 603
ALA A 607
ALA A 604
 None
 1.15A 2ej3B-2yiaA:
undetectable		 2ej3B-2yiaA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 8 ARG A 639
GLY A 651
GLY A 603
ALA A 607
ALA A 604
 None
 1.17A 2ej3C-2yiaA:
undetectable		 2ej3C-2yiaA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA602_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 5 HIS A 362
ILE A 683
PRO A 360
ASP A 665
 None
 1.45A 2f7fA-2yiaA:
0.0		 2f7fA-2yiaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 ARG A 786
GLN A 413
PRO A 412
 None
 0.96A 2qhfA-2yiaA:
undetectable		 2qhfA-2yiaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 THR A 337
VAL A 335
SER A 336
PRO A 239
 None
 1.06A 2v2gA-2yiaA:
undetectable
2v2gB-2yiaA:
undetectable		 2v2gA-2yiaA:
14.27
2v2gB-2yiaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 PRO A 239
THR A 337
VAL A 335
SER A 336
 None
 1.06A 2v2gC-2yiaA:
undetectable
2v2gD-2yiaA:
undetectable		 2v2gC-2yiaA:
14.27
2v2gD-2yiaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 THR A 337
VAL A 335
SER A 336
PRO A 239
 None
 1.06A 2v41E-2yiaA:
undetectable
2v41F-2yiaA:
undetectable		 2v41E-2yiaA:
14.27
2v41F-2yiaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 PRO A 239
THR A 337
VAL A 335
SER A 336
 None
 1.06A 2v41E-2yiaA:
undetectable
2v41F-2yiaA:
undetectable		 2v41E-2yiaA:
14.27
2v41F-2yiaA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 GLN A 570
ILE A 683
SER A 568
TYR A 540
 None
 1.26A 2xz5D-2yiaA:
undetectable
2xz5E-2yiaA:
undetectable		 2xz5D-2yiaA:
13.62
2xz5E-2yiaA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 5 THR A 733
THR A 411
HIS A 414
LEU A 482
 None
 1.35A 2zj0A-2yiaA:
undetectable		 2zj0A-2yiaA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 12 LEU A 200
ILE A 207
ILE A 486
GLU A 490
ALA A 489
 None
 1.14A 3axtA-2yiaA:
undetectable		 3axtA-2yiaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 5 THR A 733
THR A 411
HIS A 414
LEU A 482
 None
 1.33A 3ce6A-2yiaA:
undetectable		 3ce6A-2yiaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 5 THR A 733
THR A 411
HIS A 414
LEU A 482
 None
 1.32A 3ce6C-2yiaA:
undetectable		 3ce6C-2yiaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 ARG A 695
ASP A 707
GLN A 394
 None
 0.94A 3lcvB-2yiaA:
undetectable		 3lcvB-2yiaA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 11 VAL A 611
LEU A 653
GLY A 603
ALA A 604
LEU A 593
 None
 1.05A 3n8yA-2yiaA:
undetectable		 3n8yA-2yiaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 TYR A 589
LEU A 618
ARG A 612
 None
 0.79A 3sufB-2yiaA:
undetectable		 3sufB-2yiaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 6 PRO A 141
GLY A 143
LEU A 135
ASN A 138
 None
 0.83A 3zqtA-2yiaA:
undetectable		 3zqtA-2yiaA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 6 ASP A 388
THR A 485
ILE A 385
PHE A 477
 None
 1.02A 4acbC-2yiaA:
undetectable		 4acbC-2yiaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 12 ILE A 321
TYR A 106
GLY A 248
ALA A 247
SER A 246
 None
 1.10A 4e1gB-2yiaA:
2.1		 4e1gB-2yiaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 8 GLY A 620
PRO A 576
PHE A 361
ILE A 683
 None
 0.98A 4j4vC-2yiaA:
undetectable		 4j4vC-2yiaA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 8 LYS A 632
ALA A 631
GLY A 621
LEU A 627
LEU A 127
 None
 1.49A 4po0A-2yiaA:
undetectable		 4po0A-2yiaA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 GLU A 404
LYS A 516
ASN A 514
 None
None
K  A1002 (-3.5A)
 0.81A 4y1dA-2yiaA:
undetectable
4y1dD-2yiaA:
undetectable		 4y1dA-2yiaA:
13.42
4y1dD-2yiaA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 5 THR A 739
GLU A 784
THR A 785
LEU A 274
 None
 1.10A 5hm8G-2yiaA:
undetectable		 5hm8G-2yiaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 LYS A 632
GLN A 678
ASN A 677
 None
 0.92A 5l2tA-2yiaA:
undetectable		 5l2tA-2yiaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 THR A 439
PRO A 434
ARG A 435
 None
 0.85A 5nd7B-2yiaA:
undetectable		 5nd7B-2yiaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 THR A 442
PRO A 434
ARG A 435
 None
 0.83A 5nd7B-2yiaA:
undetectable		 5nd7B-2yiaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 4 LEU A 345
MET A 340
ILE A 347
LEU A 205
 None
 1.42A 5nfpA-2yiaA:
undetectable		 5nfpA-2yiaA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 GLY A 470
GLN A 413
ASP A 454
TYR A 467
 None
 1.28A 5vlmG-2yiaA:
1.4		 5vlmG-2yiaA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		3 / 3 TYR A 356
HIS A 481
PHE A 477
 None
 1.05A 6esmA-2yiaA:
undetectable		 6esmA-2yiaA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		5 / 11 GLN A 469
GLY A 472
PRO A 338
LEU A 422
MET A 415
 None
 1.49A 6euqA-2yiaA:
0.0		 6euqA-2yiaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2yia RNA-DIRECTED RNA
POLYMERASE
(Infectious
pancreatic
necrosis
virus) 		4 / 7 VAL A 488
ILE A 513
GLY A 472
ALA A 387
 None
 0.89A 6hd6B-2yiaA:
undetectable		 6hd6B-2yiaA:
8.42