SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 GLY D 621
LEU D 583
VAL D 150
LEU D 127
ALA D 630
None
1.10A 1gseB-2yibD:
2.0
1gseB-2yibD:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 SER D 586
VAL D 619
LEU D 578
None
0.65A 1yajG-2yibD:
undetectable
1yajG-2yibD:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 8 SER D 269
VAL D 265
LEU D 266
PRO D  96
None
0.91A 2ddwA-2yibD:
undetectable
2ddwA-2yibD:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 10 ARG D 639
GLY D 651
GLY D 603
ALA D 607
ALA D 604
None
1.18A 2ej3B-2yibD:
undetectable
2ej3B-2yibD:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
6 / 12 SER D 660
GLY D 664
GLY D 663
ASN D 657
ALA D 615
GLY D 668
None
1.45A 2pkkA-2yibD:
undetectable
2pkkA-2yibD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
6 / 12 SER D 660
GLY D 664
GLY D 663
ASN D 657
ALA D 615
GLY D 668
None
1.47A 2pkmA-2yibD:
undetectable
2pkmA-2yibD:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 THR D 337
VAL D 335
SER D 336
PRO D 239
None
1.03A 2v2gA-2yibD:
undetectable
2v2gB-2yibD:
undetectable
2v2gA-2yibD:
14.77
2v2gB-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 PRO D 239
THR D 337
VAL D 335
SER D 336
None
1.05A 2v2gA-2yibD:
undetectable
2v2gB-2yibD:
undetectable
2v2gA-2yibD:
14.77
2v2gB-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 PRO D 239
THR D 337
VAL D 335
SER D 336
None
1.03A 2v2gC-2yibD:
undetectable
2v2gD-2yibD:
undetectable
2v2gC-2yibD:
14.77
2v2gD-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 THR D 337
VAL D 335
SER D 336
PRO D 239
None
1.02A 2v41E-2yibD:
undetectable
2v41F-2yibD:
undetectable
2v41E-2yibD:
14.77
2v41F-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 PRO D 239
THR D 337
VAL D 335
SER D 336
None
1.03A 2v41E-2yibD:
undetectable
2v41F-2yibD:
undetectable
2v41E-2yibD:
14.77
2v41F-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 8 PRO D 239
THR D 337
VAL D 335
SER D 336
None
1.02A 2v41G-2yibD:
undetectable
2v41H-2yibD:
undetectable
2v41G-2yibD:
14.77
2v41H-2yibD:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 GLN D 570
ILE D 683
SER D 568
TYR D 540
None
1.28A 2xz5D-2yibD:
undetectable
2xz5E-2yibD:
undetectable
2xz5D-2yibD:
15.81
2xz5E-2yibD:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 11 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
0.99A 3n8yA-2yibD:
undetectable
3n8yA-2yibD:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 6 PRO D 141
GLY D 143
LEU D 135
ASN D 138
None
0.83A 3zqtA-2yibD:
undetectable
3zqtA-2yibD:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 6 ASP D 388
THR D 485
ILE D 385
PHE D 477
None
1.03A 4acbC-2yibD:
undetectable
4acbC-2yibD:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 8 LYS D 632
ALA D 631
GLY D 621
LEU D 627
LEU D 127
None
1.46A 4po0A-2yibD:
undetectable
4po0A-2yibD:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.04A 4rrwA-2yibD:
undetectable
4rrwA-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.06A 4rrwC-2yibD:
undetectable
4rrwC-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.09A 4rrxA-2yibD:
undetectable
4rrxA-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.07A 4rrxB-2yibD:
undetectable
4rrxB-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.04A 4rrzA-2yibD:
undetectable
4rrzA-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
5 / 12 VAL D 611
LEU D 653
GLY D 603
ALA D 604
LEU D 593
None
1.06A 4rrzC-2yibD:
undetectable
4rrzC-2yibD:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 GLU D 404
LYS D 516
ASN D 514
None
0.80A 4y1dA-2yibD:
undetectable
4y1dD-2yibD:
undetectable
4y1dA-2yibD:
13.81
4y1dD-2yibD:
0.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 LYS D 632
GLN D 678
ASN D 677
None
0.95A 5l2tA-2yibD:
undetectable
5l2tA-2yibD:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 THR D 439
PRO D 434
ARG D 435
None
0.85A 5nd7B-2yibD:
undetectable
5nd7B-2yibD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 THR D 442
PRO D 434
ARG D 435
None
0.83A 5nd7B-2yibD:
undetectable
5nd7B-2yibD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 GLY D 470
GLN D 413
ASP D 454
TYR D 467
None
1.28A 5vlmG-2yibD:
1.6
5vlmG-2yibD:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 8 GLY D 668
ILE D 669
ASP D 665
PRO D 360
None
1.06A 6ag0C-2yibD:
undetectable
6ag0C-2yibD:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
3 / 3 TYR D 356
HIS D 481
PHE D 477
None
1.03A 6esmA-2yibD:
undetectable
6esmA-2yibD:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis
virus)
4 / 7 VAL D 488
ILE D 513
GLY D 472
ALA D 387
None
0.87A 6hd6B-2yibD:
undetectable
6hd6B-2yibD:
9.13