SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yik'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ALA A 292
LEU A 245
ALA A 248
LYS A 249
 None
 0.58A 1e7cA-2yikA:
0.8		 1e7cA-2yikA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A 434
LEU A 428
GLY A 430
TYR A 427
 None
 0.93A 1gtiB-2yikA:
2.2		 1gtiB-2yikA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A 225
GLY A 124
ALA A 221
ILE A 218
 None
 0.77A 1gtnA-2yikA:
undetectable
1gtnB-2yikA:
undetectable		 1gtnA-2yikA:
8.51
1gtnB-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.74A 1gtnP-2yikA:
undetectable
1gtnQ-2yikA:
undetectable		 1gtnP-2yikA:
8.51
1gtnQ-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.09A 1jb0B-2yikA:
undetectable		 1jb0B-2yikA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 329
LEU A 291
HIS A 409
TYR A 139
GLU A 140
 None
 1.43A 1mmkA-2yikA:
undetectable		 1mmkA-2yikA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A 121
ARG A 394
GLU A 496
ASP A 119
 None
 1.11A 1s3zA-2yikA:
undetectable
1s3zB-2yikA:
undetectable		 1s3zA-2yikA:
13.76
1s3zB-2yikA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 VAL A 184
VAL A 110
GLU A 127
ARG A 204
ASP A  76
 None
None
None
ZN  A1533 ( 4.8A)
None
 1.07A 1t6zB-2yikA:
undetectable		 1t6zB-2yikA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.76A 1utdB-2yikA:
undetectable
1utdC-2yikA:
undetectable		 1utdB-2yikA:
8.51
1utdC-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.76A 1utdF-2yikA:
undetectable
1utdG-2yikA:
undetectable		 1utdF-2yikA:
8.51
1utdG-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.77A 1utdJ-2yikA:
undetectable
1utdK-2yikA:
undetectable		 1utdJ-2yikA:
8.51
1utdK-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 TYR A 501
ARG A 394
ASP A 119
ASP A 186
 None
 1.49A 1ve3A-2yikA:
0.0		 1ve3A-2yikA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A 100
PHE A 170
ARG A  78
 None
 0.63A 1xdkB-2yikA:
undetectable		 1xdkB-2yikA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A 100
PHE A 170
ARG A  78
 None
 0.63A 1xdkF-2yikA:
undetectable		 1xdkF-2yikA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLU A 127
GLY A 124
LEU A 125
PRO A 269
HIS A 115
 None
None
None
None
ZN  A1533 (-3.4A)
 1.22A 2h21B-2yikA:
undetectable		 2h21B-2yikA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A 277
GLY A 313
PRO A 312
 CA  A1333 (-4.7A)
None
None
 0.88A 2hreB-2yikA:
undetectable		 2hreB-2yikA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 ILE A 328
ALA A 287
ALA A 286
VAL A 405
ILE A 402
 None
 1.08A 3falA-2yikA:
undetectable		 3falA-2yikA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLN A 144
LEU A 158
ARG A 146
PHE A 145
 None
 0.99A 3ln1C-2yikA:
undetectable		 3ln1C-2yikA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.09A 3pcqB-2yikA:
undetectable		 3pcqB-2yikA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 SER A 446
PRO A 450
TYR A 449
VAL A 476
 None
 1.41A 3sufC-2yikA:
undetectable		 3sufC-2yikA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 222
VAL A 321
VAL A 134
PHE A 165
PHE A 161
 None
 1.34A 3tbgA-2yikA:
undetectable		 3tbgA-2yikA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 THR A 222
VAL A 321
VAL A 134
PHE A 165
PHE A 161
 None
 1.33A 3tbgC-2yikA:
undetectable		 3tbgC-2yikA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ASP A 281
GLN A 183
HIS A 182
GLY A 268
PRO A 126
 CA  A1333 (-2.9A)
None
None
None
None
 1.46A 3v3oC-2yikA:
0.0		 3v3oC-2yikA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A  61
ARG A 167
CYH A  72
GLU A  62
HIS A 115
 None
None
ZN  A1533 (-2.3A)
None
ZN  A1533 (-3.4A)
 1.32A 4feuA-2yikA:
undetectable
4feuB-2yikA:
undetectable		 4feuA-2yikA:
17.14
4feuB-2yikA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A  61
ARG A 167
CYH A  72
GLU A  62
HIS A 115
 None
None
ZN  A1533 (-2.3A)
None
ZN  A1533 (-3.4A)
 1.28A 4fewC-2yikA:
0.0
4fewD-2yikA:
0.0
4fewF-2yikA:
0.0		 4fewC-2yikA:
17.14
4fewD-2yikA:
17.14
4fewF-2yikA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ASP A  61
ARG A 167
CYH A  72
GLU A  62
HIS A 115
 None
None
ZN  A1533 (-2.3A)
None
ZN  A1533 (-3.4A)
 1.29A 4gkhA-2yikA:
0.0
4gkhB-2yikA:
0.0		 4gkhA-2yikA:
17.14
4gkhB-2yikA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ASP A  61
ARG A 167
CYH A  72
GLU A  62
HIS A 115
 None
None
ZN  A1533 (-2.3A)
None
ZN  A1533 (-3.4A)
 1.29A 4gkiI-2yikA:
0.0
4gkiJ-2yikA:
0.0		 4gkiI-2yikA:
17.14
4gkiJ-2yikA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A 247
VAL A 177
ILE A 219
ALA A 223
 None
 0.90A 4lv9B-2yikA:
undetectable		 4lv9B-2yikA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 TYR A 138
ARG A 146
LYS A 142
 None
 1.13A 4wq5B-2yikA:
undetectable		 4wq5B-2yikA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.09A 4xk8B-2yikA:
undetectable		 4xk8B-2yikA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A 502
ILE A 402
ILE A 315
SER A 323
HIS A 316
 None
 1.38A 4xueA-2yikA:
undetectable		 4xueA-2yikA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ASN A 495
VAL A 476
ALA A 474
GLY A 441
 None
 0.93A 5fpdA-2yikA:
undetectable		 5fpdA-2yikA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 4 GLY A 137
ALA A 510
MET A  48
THR A 148
 None
 1.14A 5n0sB-2yikA:
undetectable		 5n0sB-2yikA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.09A 5oy02-2yikA:
1.1		 5oy02-2yikA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		5 / 10 TRP A 136
ILE A 315
ALA A 398
LEU A 401
ALA A 508
 None
 1.08A 5zjiB-2yikA:
undetectable		 5zjiB-2yikA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yik ENDOGLUCANASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 TRP A 284
ASP A 217
HIS A 316
ASP A 320
 None
 1.22A 6mn4D-2yikA:
undetectable		 6mn4D-2yikA:
17.51