SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yiu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 12 VAL A 161
GLY A 164
LEU A 165
GLY A 158
PHE A 194
 SMA  A 502 (-4.3A)
None
None
SMA  A 502 (-3.5A)
SMA  A 502 (-4.5A)
 1.01A 1fduA-2yiuA:
undetectable		 1fduA-2yiuA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 12 VAL A 161
GLY A 164
LEU A 165
GLY A 158
MET A 336
 SMA  A 502 (-4.3A)
None
None
SMA  A 502 (-3.5A)
SMA  A 502 (-3.6A)
 1.09A 1fduC-2yiuA:
undetectable		 1fduC-2yiuA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		3 / 3 MET A  84
ASN A  99
GLN A  58
 None
None
HEM  A 500 (-4.4A)
 0.95A 1xoqB-2yiuA:
undetectable		 1xoqB-2yiuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		5 / 11 LEU B  96
PHE B 135
ASP B 146
GLY B  87
TYR B  78
 None
 1.25A 1zz1A-2yiuB:
undetectable		 1zz1A-2yiuB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		4 / 7 VAL A 314
VAL A 318
LEU A 321
SER A 322
 None
 0.69A 3hs6B-2yiuA:
undetectable		 3hs6B-2yiuA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA500_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2yiu UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT
(Paracoccus
denitrificans) 		4 / 4 ALA C 170
HIS C 134
HIS C 155
PRO C 169
 None
FES  C 500 (-3.0A)
FES  C 500 ( 3.0A)
FES  C 500 ( 4.9A)
 1.39A 3mbgA-2yiuC:
undetectable		 3mbgA-2yiuC:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC900_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2yiu UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT
(Paracoccus
denitrificans) 		4 / 4 ALA C 170
HIS C 134
HIS C 155
PRO C 169
 None
FES  C 500 (-3.0A)
FES  C 500 ( 3.0A)
FES  C 500 ( 4.9A)
 1.40A 3mbgC-2yiuC:
undetectable		 3mbgC-2yiuC:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 2yiu CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT
(Paracoccus
denitrificans) 		4 / 7 PHE A 264
ALA C  34
LEU A  93
LEU A  96
 None
 0.92A 4ejgC-2yiuA:
undetectable		 4ejgC-2yiuA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 112
VAL B  91
PHE B 239
LEU B  75
 None
 0.94A 4f8hA-2yiuB:
undetectable
4f8hB-2yiuB:
undetectable		 4f8hA-2yiuB:
20.35
4f8hB-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 112
VAL B  91
PHE B 239
LEU B  75
 None
 0.93A 4f8hB-2yiuB:
undetectable
4f8hC-2yiuB:
undetectable		 4f8hB-2yiuB:
20.35
4f8hC-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 112
VAL B  91
PHE B 239
LEU B  75
 None
 0.94A 4f8hC-2yiuB:
undetectable
4f8hD-2yiuB:
undetectable		 4f8hC-2yiuB:
20.35
4f8hD-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 112
VAL B  91
PHE B 239
LEU B  75
 None
 0.93A 4f8hD-2yiuB:
undetectable
4f8hE-2yiuB:
undetectable		 4f8hD-2yiuB:
20.35
4f8hE-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 VAL B  91
PHE B 239
LEU B  75
TYR B 112
 None
 0.93A 4f8hA-2yiuB:
undetectable
4f8hE-2yiuB:
undetectable		 4f8hA-2yiuB:
20.35
4f8hE-2yiuB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 2yiu CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT
(Paracoccus
denitrificans) 		5 / 12 LEU A 253
LEU A 256
ALA A 257
ALA C  30
THR B 272
 None
 0.71A 4fn9A-2yiuA:
undetectable		 4fn9A-2yiuA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		5 / 10 PHE B 116
TYR B 112
THR B  79
THR B 243
VAL B  91
 None
 1.09A 4jx1B-2yiuB:
undetectable		 4jx1B-2yiuB:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2yiu UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT
(Paracoccus
denitrificans) 		3 / 3 VAL C  76
GLY C 130
LYS C  74
 None
 0.76A 4k50E-2yiuC:
undetectable		 4k50E-2yiuC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 12 LEU A  96
ASN A  99
GLY A 100
GLN A  58
LEU A  65
 None
None
None
HEM  A 500 (-4.4A)
HEM  A 500 ( 4.6A)
 1.39A 4p6xA-2yiuA:
undetectable		 4p6xA-2yiuA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		9 / 12 GLY A 158
VAL A 161
ILE A 162
ILE A 292
PRO A 294
PHE A 301
LEU A 305
MET A 336
ILE A 340
 SMA  A 502 (-3.5A)
SMA  A 502 (-4.3A)
SMA  A 502 ( 4.5A)
SMA  A 502 (-4.6A)
SMA  A 502 ( 3.8A)
None
SMA  A 502 ( 4.4A)
SMA  A 502 (-3.6A)
None
 0.78A 4pd4C-2yiuA:
50.0		 4pd4C-2yiuA:
44.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		9 / 12 GLY A 158
VAL A 161
ILE A 162
PRO A 294
PHE A 301
TYR A 302
LEU A 305
MET A 336
ILE A 340
 SMA  A 502 (-3.5A)
SMA  A 502 (-4.3A)
SMA  A 502 ( 4.5A)
SMA  A 502 ( 3.8A)
None
SMA  A 502 (-4.5A)
SMA  A 502 ( 4.4A)
SMA  A 502 (-3.6A)
None
 0.56A 4pd4C-2yiuA:
50.0		 4pd4C-2yiuA:
44.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 11 ALA A  76
VAL A 186
GLY A 146
SER A 155
GLY A 158
 None
None
HEM  A 500 (-3.5A)
None
SMA  A 502 (-3.5A)
 1.27A 4xp4A-2yiuA:
undetectable		 4xp4A-2yiuA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		4 / 7 GLY A 158
PHE A 166
LEU A 180
GLU A 295
 SMA  A 502 (-3.5A)
SMA  A 502 ( 4.7A)
SMA  A 502 ( 4.2A)
SMA  A 502 (-2.5A)
 0.84A 5izfA-2yiuA:
undetectable		 5izfA-2yiuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		3 / 3 PRO B 121
ARG B 127
GLU B 122
 None
 0.82A 5j6hA-2yiuB:
undetectable		 5j6hA-2yiuB:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		4 / 6 HIS A 291
VAL A 293
TYR A 302
ARG A 306
 None
None
SMA  A 502 (-4.5A)
None
 0.45A 5kkzA-2yiuA:
57.1
5kkzG-2yiuA:
undetectable		 5kkzA-2yiuA:
83.37
5kkzG-2yiuA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 7 HIS A 291
ILE A 292
VAL A 293
TYR A 302
ARG A 306
 None
SMA  A 502 (-4.6A)
None
SMA  A 502 (-4.5A)
None
 0.41A 5kkzC-2yiuA:
undetectable
5kkzE-2yiuA:
57.0		 5kkzC-2yiuA:
18.16
5kkzE-2yiuA:
83.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 7 HIS A 291
ILE A 292
VAL A 293
TYR A 302
ARG A 306
 None
SMA  A 502 (-4.6A)
None
SMA  A 502 (-4.5A)
None
 0.42A 5kkzK-2yiuA:
60.8
5kkzQ-2yiuA:
undetectable		 5kkzK-2yiuA:
83.37
5kkzQ-2yiuA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 7 HIS A 291
ILE A 292
VAL A 293
TYR A 302
ARG A 306
 None
SMA  A 502 (-4.6A)
None
SMA  A 502 (-4.5A)
None
 0.41A 5kkzM-2yiuA:
undetectable
5kkzO-2yiuA:
57.1		 5kkzM-2yiuA:
18.16
5kkzO-2yiuA:
83.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 221
THR B 234
CYH B  82
LEU B 214
 None
None
HEC  B 500 (-1.6A)
HEC  B 500 ( 4.5A)
 1.43A 5kxiA-2yiuB:
undetectable
5kxiB-2yiuB:
undetectable		 5kxiA-2yiuB:
19.54
5kxiB-2yiuB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2yiu CYTOCHROME C1, HEME
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 TYR B 221
THR B 234
CYH B  82
LEU B 214
 None
None
HEC  B 500 (-1.6A)
HEC  B 500 ( 4.5A)
 1.36A 5kxiD-2yiuB:
undetectable
5kxiE-2yiuB:
undetectable		 5kxiD-2yiuB:
19.54
5kxiE-2yiuB:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2yiu CYTOCHROME B
(Paracoccus
denitrificans) 		5 / 10 TRP A  44
PHE A 374
TYR A 117
TYR A 118
PHE A 367
 None
 1.16A 6hu9C-2yiuA:
5.0		 6hu9C-2yiuA:
44.18