SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 HIS A 245
ILE A 241
VAL A 419
SER A  28
 None
 0.97A 1kb9A-2yjgA:
undetectable
1kb9C-2yjgA:
undetectable
1kb9D-2yjgA:
undetectable
1kb9E-2yjgA:
undetectable		 1kb9A-2yjgA:
23.38
1kb9C-2yjgA:
21.87
1kb9D-2yjgA:
20.05
1kb9E-2yjgA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 ILE A   6
ASP A  16
LEU A 399
ARG A  27
 None
 1.19A 2a7qA-2yjgA:
undetectable		 2a7qA-2yjgA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 LEU A 147
ALA A 231
ILE A 144
ILE A 155
ALA A 191
 None
 0.91A 2bxcA-2yjgA:
undetectable		 2bxcA-2yjgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 9 ILE A 236
ILE A  68
GLY A 169
GLU A 168
ALA A 167
 None
 1.19A 2dtjA-2yjgA:
undetectable
2dtjB-2yjgA:
undetectable		 2dtjA-2yjgA:
16.48
2dtjB-2yjgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 GLY A 110
ASN A 156
THR A 105
GLY A 106
HIS A 133
 None
 1.48A 2hmaA-2yjgA:
undetectable		 2hmaA-2yjgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 LEU A 147
SER A 192
ILE A 196
ALA A 191
ALA A 227
 None
 1.17A 2japA-2yjgA:
2.1		 2japA-2yjgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 LEU A  86
LEU A  83
LEU A  47
PRO A  78
 None
 0.92A 2vq5B-2yjgA:
undetectable		 2vq5B-2yjgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 10 ILE A 313
ALA A 302
ILE A 315
ILE A   6
THR A 301
 None
 1.12A 2w9sC-2yjgA:
undetectable		 2w9sC-2yjgA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
 0.98A 2x1lA-2yjgA:
undetectable		 2x1lA-2yjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 12 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
 1.00A 2x1lB-2yjgA:
undetectable		 2x1lB-2yjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		5 / 11 ALA A 231
ALA A 159
HIS A 133
GLY A 189
ILE A 144
 None
 1.02A 2x1lC-2yjgA:
3.0		 2x1lC-2yjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 GLY A 285
GLY A 286
GLY A   9
SER A 283
 None
 0.49A 3d41A-2yjgA:
undetectable		 3d41A-2yjgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 6 ILE A 405
ALA A 402
ALA A 392
THR A 390
 None
 1.06A 3mdrB-2yjgA:
undetectable		 3mdrB-2yjgA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 HIS A 221
ARG A 183
GLU A 256
 None
 0.92A 3qf1A-2yjgA:
undetectable		 3qf1A-2yjgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		3 / 3 ASN A  94
ALA A  60
LYS A  63
 None
 0.57A 3runA-2yjgA:
undetectable		 3runA-2yjgA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 8 TYR A 381
VAL A 384
ILE A 293
GLU A 397
 None
 0.93A 4a97D-2yjgA:
undetectable		 4a97D-2yjgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 TYR A 381
VAL A 384
ILE A 293
GLU A 397
 None
 1.04A 4a97H-2yjgA:
undetectable		 4a97H-2yjgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 VAL A 372
ILE A 373
LEU A  13
LEU A 395
 None
 0.88A 4xo7A-2yjgA:
undetectable		 4xo7A-2yjgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 ILE A 362
GLY A 299
THR A 282
MET A 374
 None
 0.95A 4zdzA-2yjgA:
undetectable		 4zdzA-2yjgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 4 CYH A 195
LEU A 153
LEU A 187
ALA A 227
 None
 1.12A 5hpuA-2yjgA:
undetectable
5hpuB-2yjgA:
undetectable		 5hpuA-2yjgA:
4.43
5hpuB-2yjgA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 SER A  79
THR A  82
VAL A  43
ILE A 236
 None
 1.25A 5vkqA-2yjgA:
undetectable
5vkqB-2yjgA:
undetectable		 5vkqA-2yjgA:
13.05
5vkqB-2yjgA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yjg LACTATE RACEMASE
APOPROTEIN
(Thermoanaerobact
erium
thermosaccharoly
ticum) 		4 / 7 SER A  79
THR A  82
VAL A  43
ILE A 236
 None
 1.23A 5vkqC-2yjgA:
undetectable
5vkqD-2yjgA:
undetectable		 5vkqC-2yjgA:
13.05
5vkqD-2yjgA:
13.05