SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yjp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 8 LEU A 208
VAL A 142
LEU A 202
ALA A 168
 None
 0.84A 1fiqC-2yjpA:
undetectable		 1fiqC-2yjpA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 ILE A  50
GLY A  87
SER A  88
ALA A  82
LEU A  85
 None
 1.21A 1i9gA-2yjpA:
undetectable		 1i9gA-2yjpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 252
VAL A 247
TRP A 246
 None
 0.85A 1kqeA-2yjpA:
undetectable
1kqeE-2yjpA:
undetectable		 1kqeA-2yjpA:
5.06
1kqeE-2yjpA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 252
VAL A 247
TRP A 246
 None
 0.82A 1kqeB-2yjpA:
undetectable
1kqeD-2yjpA:
undetectable		 1kqeB-2yjpA:
5.06
1kqeD-2yjpA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 TRP A 246
ALA A 252
VAL A 247
 None
 0.84A 1kqeB-2yjpA:
undetectable
1kqeD-2yjpA:
undetectable		 1kqeB-2yjpA:
5.06
1kqeD-2yjpA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 TRP A 246
ALA A 252
VAL A 247
 None
 0.82A 1kqeA-2yjpA:
undetectable
1kqeE-2yjpA:
undetectable		 1kqeA-2yjpA:
5.06
1kqeE-2yjpA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 5 MET A 254
ALA A 252
ILE A 251
ASP A  84
 None
 0.84A 1upfA-2yjpA:
undetectable		 1upfA-2yjpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 7 MET A 254
ALA A 252
ILE A 251
ASP A  84
 None
 0.88A 1upfB-2yjpA:
undetectable		 1upfB-2yjpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 5 MET A 254
ALA A 252
ILE A 251
ASP A  84
 None
 0.91A 1upfC-2yjpA:
undetectable		 1upfC-2yjpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 GLY A  53
LEU A 260
ASN A 117
ALA A 116
VAL A  54
 None
 1.06A 3av6A-2yjpA:
undetectable		 3av6A-2yjpA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 9 ILE A 251
ALA A 131
PHE A 130
LYS A  79
LEU A 113
 None
 1.30A 3ti1A-2yjpA:
undetectable		 3ti1A-2yjpA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 ALA A 283
LEU A 260
MET A 254
ALA A 233
ILE A  77
 None
 1.17A 3ut5D-2yjpA:
undetectable		 3ut5D-2yjpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 9 SER A 108
ILE A 114
GLY A  53
THR A  97
ASP A 112
 None
 1.24A 4fxsA-2yjpA:
undetectable		 4fxsA-2yjpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 8 ILE A 223
HIS A 204
THR A 166
THR A 167
 None
CYS  A 350 (-4.7A)
CYS  A 350 (-4.5A)
CYS  A 350 (-3.4A)
 0.81A 4n16A-2yjpA:
undetectable		 4n16A-2yjpA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 ASP A  80
LYS A 255
LEU A 282
 None
 0.91A 4ptjA-2yjpA:
undetectable		 4ptjA-2yjpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 ASP A  80
LEU A  81
ARG A 259
LEU A 260
ILE A  77
 None
 1.07A 4x1fA-2yjpA:
undetectable		 4x1fA-2yjpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 ASP A  80
LEU A  81
ARG A 259
LEU A 260
ILE A  77
 None
 1.08A 4x1gA-2yjpA:
undetectable		 4x1gA-2yjpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 ILE A  77
ILE A 232
MET A 254
 None
 0.65A 5i9yA-2yjpA:
undetectable		 5i9yA-2yjpA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 VAL A 247
ASN A 248
ILE A 251
ALA A 252
LYS A 255
 None
 0.48A 5j2tC-2yjpA:
undetectable		 5j2tC-2yjpA:
21.32