SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yjv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 LEU A  51
GLY A  34
GLY A  58
ILE A  37
LEU A  73
 None
 1.07A 1p91B-2yjvA:
undetectable		 1p91B-2yjvA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		4 / 5 LEU A 153
HIS A 143
ILE A  36
PHE A 139
 None
 0.85A 1xf1A-2yjvA:
3.9		 1xf1A-2yjvA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		4 / 6 LEU A 153
HIS A 143
ILE A  36
PHE A 139
 None
 0.82A 1xf1B-2yjvA:
2.9		 1xf1B-2yjvA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 LEU A  61
ASP A 128
ILE A  37
ASP A  44
GLY A 123
 None
 1.13A 1zz1C-2yjvA:
undetectable		 1zz1C-2yjvA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 VAL A  96
ALA A 113
PHE A  23
PHE A 138
VAL A  60
 None
 1.20A 4eckA-2yjvA:
undetectable		 4eckA-2yjvA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 8 LEU A  51
LEU A  48
LEU A  73
ILE A  37
VAL A 131
 None
 1.45A 4klaA-2yjvA:
undetectable		 4klaA-2yjvA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		4 / 8 GLY A  67
ASP A  64
VAL A  91
GLY A 134
 None
 0.57A 5kr1B-2yjvA:
undetectable		 5kr1B-2yjvA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLY A  67
ASP A  64
VAL A  91
GLY A 134
SER A  24
 None
 0.77A 5t2zA-2yjvA:
undetectable		 5t2zA-2yjvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLY A  67
ASP A  64
VAL A  91
GLY A 134
SER A  24
 None
 0.61A 5t2zB-2yjvA:
undetectable		 5t2zB-2yjvA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 ARG A  71
GLY A 118
LEU A  61
GLY A  65
SER A  68
 None
 1.10A 5vooA-2yjvA:
undetectable		 5vooA-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		6 / 12 GLU A  43
ARG A  71
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.27A 5vooA-2yjvA:
undetectable		 5vooA-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 ARG A  71
GLY A 118
LEU A  61
GLY A  65
SER A  68
 None
 1.05A 5vooB-2yjvA:
undetectable		 5vooB-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLU A  43
ARG A  71
GLY A 118
GLY A  65
SER A  68
 None
 1.11A 5vooB-2yjvA:
undetectable		 5vooB-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 ARG A  71
GLY A 118
LEU A  61
GLY A  65
SER A  68
 None
 1.12A 5vooC-2yjvA:
undetectable		 5vooC-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		6 / 12 GLU A  43
ARG A  71
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.28A 5vooC-2yjvA:
undetectable		 5vooC-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLU A  43
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.16A 5vooD-2yjvA:
undetectable		 5vooD-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		6 / 12 GLU A  43
ARG A  71
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.49A 5vooE-2yjvA:
undetectable		 5vooE-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLU A  43
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.14A 5vooF-2yjvA:
undetectable		 5vooF-2yjvA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2yjv REGULATOR OF
RIBONUCLEASE
ACTIVITY A
(Escherichia
coli) 		5 / 12 GLU A  43
GLY A 118
ASP A  44
GLY A  65
SER A  68
 None
 1.15A 5vopB-2yjvA:
undetectable		 5vopB-2yjvA:
21.64