SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 2y03B-2yk1H:
undetectable		 2y03B-2yk1H:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 VAL H 198
LYS H 196
HIS H 164
 None
 0.89A 3elzA-2yk1H:
undetectable		 3elzA-2yk1H:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.53A 4o2bA-2yk1H:
undetectable		 4o2bA-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.55A 4o2bC-2yk1H:
undetectable		 4o2bC-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.54A 4x1iA-2yk1H:
undetectable		 4x1iA-2yk1H:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 SER H  28
ALA H  94
VAL H  93
 None
None
NCT  H 300 (-4.3A)
 0.53A 5eypA-2yk1H:
undetectable		 5eypA-2yk1H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2yk1 FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 VAL H  24
SER H  25
TRP H  30
 None
 1.02A 5jwaA-2yk1H:
undetectable		 5jwaA-2yk1H:
18.62