SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FML_B_RTLB501_0 (RETINOL DEHYDRATASE)	2yk3	CYTOCHROME C (Crithidia fasciculata)	5 / 12	ILE A 106 LEU A 46 LEU A 112 LEU A 79 PHE A 85	None HEM A 200 (-4.3A) None HEM A 200 (-4.4A) None	1.18A	1fmlB-2yk3A: undetectable	1fmlB-2yk3A: 14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3M7R_A_VDXA425_1 (VITAMIN D3 RECEPTOR)	2yk3	CYTOCHROME C (Crithidia fasciculata)	5 / 12	LEU A 109 LEU A 46 VAL A 47 VAL A 105 LEU A 9	None HEM A 200 (-4.3A) None None None	1.21A	3m7rA-2yk3A: undetectable	3m7rA-2yk3A: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWU_A_ACAA18_2 (WTFP-TAG,GP41)	2yk3	CYTOCHROME C (Crithidia fasciculata)	3 / 3	LEU A 112 LEU A 46 TRP A 70	None HEM A 200 (-4.3A) HEM A 200 (-4.0A)	0.94A	5nwuA-2yk3A: undetectable	5nwuA-2yk3A: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B8K_A_W9TA300_0 (GALECTIN-3)	2yk3	CYTOCHROME C (Crithidia fasciculata)	4 / 7	ARG A 6 ASN A 81 GLU A 80 ARG A 102	None	1.16A	6b8kA-2yk3A: undetectable	6b8kA-2yk3A: 20.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FML_B_RTLB501_0","RETINOL DEHYDRATASE","2yk3","CYTOCHROME C","Crithidia fasciculata",5,"ILE A 106;LEU A  46;LEU A 112;LEU A  79;PHE A  85","None;HEM A 200 (-4.3A);None;HEM A 200 (-4.4A);None","1.18A","1fmlB-2yk3A:undetectable","1fmlB-2yk3A:14.66"],["3M7R_A_VDXA425_1","VITAMIN D3 RECEPTOR","2yk3","CYTOCHROME C","Crithidia fasciculata",5,"LEU A 109;LEU A  46;VAL A  47;VAL A 105;LEU A   9","None;HEM A 200 (-4.3A);None;None;None","1.21A","3m7rA-2yk3A:undetectable","3m7rA-2yk3A:17.79"],["5NWU_A_ACAA18_2","WTFP-TAG,GP41","2yk3","CYTOCHROME C","Crithidia fasciculata",3,"LEU A 112;LEU A  46;TRP A  70","None;HEM A 200 (-4.3A);HEM A 200 (-4.0A)","0.94A","5nwuA-2yk3A:undetectable","5nwuA-2yk3A:16.67"],["6B8K_A_W9TA300_0","GALECTIN-3","2yk3","CYTOCHROME C","Crithidia fasciculata",4,"ARG A   6;ASN A  81;GLU A  80;ARG A 102","None","1.16A","6b8kA-2yk3A:undetectable","6b8kA-2yk3A:20.18"]]