SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 7 ARG A 226
ASN A 220
TYR A 176
ASN A 169
 None
 1.42A 1f9gA-2yk6A:
undetectable		 1f9gA-2yk6A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		3 / 3 TRP A 199
HIS A 211
MET A 222
 None
 1.32A 1l5qB-2yk6A:
undetectable		 1l5qB-2yk6A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		5 / 12 SER A 360
LEU A 326
ASP A 164
HIS A 211
PHE A 215
 None
 1.24A 1uobA-2yk6A:
undetectable		 1uobA-2yk6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		5 / 12 SER A 256
LEU A 253
VAL A 290
LEU A 344
TYR A 348
 None
 1.49A 2prgB-2yk6A:
undetectable		 2prgB-2yk6A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 6 TYR A 302
MET A 328
ILE A 303
SER A 295
 None
 1.26A 3pmzD-2yk6A:
undetectable		 3pmzD-2yk6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 ILE A  53
ALA A 100
HIS A  71
MET A  68
 None
 1.32A 4ac9B-2yk6A:
undetectable
4ac9C-2yk6A:
undetectable		 4ac9B-2yk6A:
23.51
4ac9C-2yk6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 ILE A  53
ALA A 100
HIS A  71
MET A  68
 None
 1.34A 4acaB-2yk6A:
undetectable
4acaC-2yk6A:
undetectable		 4acaB-2yk6A:
23.51
4acaC-2yk6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		5 / 12 ALA A 325
ILE A 299
ILE A 303
VAL A 334
ILE A 307
 None
CDP  A1374 (-4.1A)
None
None
None
 0.99A 4ax8A-2yk6A:
2.1		 4ax8A-2yk6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		5 / 12 ALA A 325
ILE A 299
ILE A 303
VAL A 334
ILE A 307
 None
CDP  A1374 (-4.1A)
None
None
None
 1.00A 4azvA-2yk6A:
2.2		 4azvA-2yk6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		5 / 12 SER A 256
LEU A 253
VAL A 290
LEU A 344
TYR A 348
 None
 1.43A 4o8fB-2yk6A:
undetectable		 4o8fB-2yk6A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 6 LEU A 344
LYS A 340
PRO A 341
GLU A 346
 None
 1.28A 4z4gA-2yk6A:
3.2		 4z4gA-2yk6A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 LEU A 125
LYS A 126
ALA A 129
LEU A 132
 None
 0.84A 5vkqA-2yk6A:
undetectable
5vkqD-2yk6A:
undetectable		 5vkqA-2yk6A:
12.17
5vkqD-2yk6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 LEU A 125
LYS A 126
ALA A 129
LEU A 132
 None
 0.83A 5vkqA-2yk6A:
undetectable
5vkqB-2yk6A:
undetectable		 5vkqA-2yk6A:
12.17
5vkqB-2yk6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 LEU A 125
LYS A 126
ALA A 129
LEU A 132
 None
 0.83A 5vkqB-2yk6A:
undetectable
5vkqC-2yk6A:
undetectable		 5vkqB-2yk6A:
12.17
5vkqC-2yk6A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2yk6 CMP-N-ACETYLNEURAMIN
ATE-BETA-GALACTOSAMI
DE-ALPHA-2,3-SIALYLT
RANSFERASE
(Neisseria
meningitidis) 		4 / 5 LEU A 125
LYS A 126
ALA A 129
LEU A 132
 None
 0.84A 5vkqC-2yk6A:
undetectable
5vkqD-2yk6A:
undetectable		 5vkqC-2yk6A:
12.17
5vkqD-2yk6A:
12.17