SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ykf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  28
LEU A  31
ARG A 261
LEU A 126
 None
BR  A1293 ( 4.6A)
None
None
 0.98A 1ereE-2ykfA:
undetectable		 1ereE-2ykfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 8 GLU A  28
LEU A  31
ARG A 261
LEU A 126
 None
BR  A1293 ( 4.6A)
None
None
 0.97A 1ereF-2ykfA:
undetectable		 1ereF-2ykfA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 115
THR A  86
GLY A  90
ARG A 117
 None
 0.82A 1h4oB-2ykfA:
undetectable		 1h4oB-2ykfA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 6 ALA A 197
LEU A 260
LEU A 215
LEU A 222
 None
 1.00A 1mt1D-2ykfA:
undetectable
1mt1E-2ykfA:
undetectable		 1mt1D-2ykfA:
17.57
1mt1E-2ykfA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 8 PRO A 115
THR A  86
GLY A  90
ARG A 117
 None
 0.83A 1oc3A-2ykfA:
undetectable		 1oc3A-2ykfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 157
LEU A 154
LEU A  31
LEU A  35
SER A  36
 None
None
BR  A1293 ( 4.6A)
None
None
 1.17A 1tz8A-2ykfA:
1.3
1tz8B-2ykfA:
1.4		 1tz8A-2ykfA:
19.35
1tz8B-2ykfA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 148
LEU A  35
SER A  36
LEU A 154
 BR  A1302 ( 4.9A)
None
None
None
 0.95A 1ya3A-2ykfA:
undetectable		 1ya3A-2ykfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 6 PHE A 181
LEU A 265
ALA A 150
LEU A 148
ALA A 145
 None
None
None
BR  A1302 ( 4.9A)
BR  A1302 ( 4.2A)
 1.31A 2vcvK-2ykfA:
undetectable		 2vcvK-2ykfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 12 MET A 204
ILE A 278
THR A 262
VAL A 236
LEU A 215
 None
 1.35A 3a51B-2ykfA:
undetectable		 3a51B-2ykfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 12 MET A 204
LEU A 222
ILE A 278
VAL A 236
LEU A 215
 None
 1.33A 3a51B-2ykfA:
undetectable		 3a51B-2ykfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 12 ASP A 185
LEU A 184
GLY A 188
ILE A 216
LEU A 240
 None
None
BR  A1300 ( 4.2A)
BR  A1300 ( 4.9A)
None
 0.92A 3cjtC-2ykfA:
undetectable		 3cjtC-2ykfA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 218
LEU A 210
ALA A 197
ILE A 278
LEU A 260
 None
 1.19A 3fl9A-2ykfA:
undetectable		 3fl9A-2ykfA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 229
VAL A 232
ASP A 233
THR A 219
 None
 0.68A 3roxA-2ykfA:
undetectable		 3roxA-2ykfA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 265
LEU A 277
MET A 156
GLU A  28
PHE A 162
 None
 1.46A 3ua5B-2ykfA:
0.0		 3ua5B-2ykfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 12 ARG A 248
PRO A 175
ALA A 197
LEU A 263
GLY A 244
 None
 1.29A 4l9qA-2ykfA:
undetectable		 4l9qA-2ykfA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 188
ALA A 197
ILE A 276
LEU A 215
LEU A 184
 BR  A1300 ( 4.2A)
None
None
None
None
 1.16A 4xj7A-2ykfA:
undetectable
4xj7B-2ykfA:
undetectable		 4xj7A-2ykfA:
24.46
4xj7B-2ykfA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 215
LEU A 184
GLY A 188
ALA A 197
ILE A 276
 None
None
BR  A1300 ( 4.2A)
None
None
 1.11A 4xj7C-2ykfA:
undetectable
4xj7D-2ykfA:
undetectable		 4xj7C-2ykfA:
24.46
4xj7D-2ykfA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 277
TYR A 146
SER A 194
 None
SO4  A1287 (-4.8A)
BR  A1289 ( 4.0A)
 0.88A 5iktA-2ykfA:
undetectable		 5iktA-2ykfA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 242
LEU A 263
VAL A 266
LEU A 265
ALA A 274
 None
 0.99A 5o96G-2ykfA:
undetectable
5o96H-2ykfA:
undetectable		 5o96G-2ykfA:
22.94
5o96H-2ykfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 235
VAL A 232
LEU A 260
THR A 262
 None
 1.32A 5ogjA-2ykfA:
undetectable		 5ogjA-2ykfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 235
VAL A 232
LEU A 260
THR A 262
 None
 1.32A 5ohhA-2ykfA:
undetectable		 5ohhA-2ykfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 181
ALA A 177
PHE A  37
THR A  61
 None
None
None
SO4  A1287 (-4.2A)
 1.17A 5t7bA-2ykfA:
undetectable		 5t7bA-2ykfA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 147
PHE A  37
ASP A  34
LEU A  41
 None
 1.09A 5uhdC-2ykfA:
0.0		 5uhdC-2ykfA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		3 / 3 LEU A   4
VAL A  19
ASP A  20
 None
 0.48A 5x23A-2ykfA:
undetectable		 5x23A-2ykfA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 4 PHE A 118
LEU A   4
LEU A  14
VAL A  25
 None
 1.19A 5xxiA-2ykfA:
undetectable		 5xxiA-2ykfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 259
ASP A 179
PRO A 175
ARG A 279
 None
 1.23A 6fgdA-2ykfA:
undetectable		 6fgdA-2ykfA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS
(Mycobacterium
tuberculosis) 		4 / 7 GLY A   5
HIS A  21
GLU A  28
GLY A  27
 None
 0.88A 6n7fA-2ykfA:
undetectable		 6n7fA-2ykfA:
14.05