SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ykq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		5 / 12 PHE A 186
ALA A 234
LEU A 231
ILE A 200
ILE A 247
 None
 1.06A 1crbA-2ykqA:
undetectable		 1crbA-2ykqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		3 / 3 GLU A 228
LYS A 223
VAL A 224
 None
 0.83A 1l2iA-2ykqA:
undetectable		 1l2iA-2ykqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		4 / 5 LEU A 160
PRO A 164
VAL A 163
ILE A 247
 None
 0.99A 2aoiB-2ykqA:
undetectable		 2aoiB-2ykqA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		4 / 7 LEU A 249
PRO A 214
GLU A 169
ARG A 202
 None
 1.03A 2jn3A-2ykqA:
undetectable		 2jn3A-2ykqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		4 / 8 ILE A 217
ILE A 247
LEU A 242
ILE A 181
 None
 0.89A 4dtaB-2ykqA:
undetectable		 4dtaB-2ykqA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		3 / 3 GLN A 147
THR A 257
ASP A 151
 None
 0.84A 5k9dA-2ykqA:
undetectable		 5k9dA-2ykqA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		5 / 7 ILE A 181
LEU A 178
ARG A 248
THR A 250
LEU A 158
 None
 1.39A 5zcpA-2ykqA:
undetectable
5zcpJ-2ykqA:
2.6		 5zcpA-2ykqA:
16.76
5zcpJ-2ykqA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2ykq LINE-1 ORF1P
(Homo
sapiens) 		4 / 8 LEU A 178
VAL A 163
LEU A 160
ILE A 247
 None
 0.83A 6cb4A-2ykqA:
undetectable		 6cb4A-2ykqA:
20.44