SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 ALA A  81
ASP A  76
ILE A  66
GLY A  69
PHE A  85
 None
 1.12A 1d4sA-2ykyA:
undetectable		 1d4sA-2ykyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 5 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.37A 1dfoB-2ykyA:
21.7		 1dfoB-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 5 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.37A 1dfoA-2ykyA:
20.7		 1dfoA-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 5 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.37A 1dfoD-2ykyA:
20.7		 1dfoD-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 5 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.36A 1dfoC-2ykyA:
21.8		 1dfoC-2ykyA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.94A 1eizA-2ykyA:
2.5		 1eizA-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 372
GLY A 224
GLY A 226
LEU A 368
PHE A 348
 None
None
None
SFE  A1447 (-4.9A)
None
 0.92A 1ej0A-2ykyA:
2.7		 1ej0A-2ykyA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.24A 1jb0A-2ykyA:
undetectable		 1jb0A-2ykyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 8 LEU A 207
CYH A 214
GLY A 247
LEU A 239
 None
 0.94A 1jlbA-2ykyA:
undetectable		 1jlbA-2ykyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 4 ALA A  20
ARG A  27
GLN A 393
GLU A 396
 None
 1.25A 1lqtB-2ykyA:
1.9		 1lqtB-2ykyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 4 ALA A  20
ARG A  27
GLN A 393
GLU A 396
 None
 1.28A 1lquB-2ykyA:
1.4		 1lquB-2ykyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 4 ALA A 324
VAL A 105
ALA A 104
HIS A 326
 None
 1.10A 1q23A-2ykyA:
undetectable		 1q23A-2ykyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 6 PHE A 141
VAL A 139
PHE A 288
SER A 258
 None
 1.01A 1wrlB-2ykyA:
undetectable		 1wrlB-2ykyA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 425
ARG A  73
ASP A 427
ALA A 428
ALA A 432
 None
 1.14A 2br4E-2ykyA:
2.6		 2br4E-2ykyA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 LEU A 341
HIS A  98
ILE A 332
ILE A 101
TYR A 333
 None
 1.36A 2efjA-2ykyA:
undetectable		 2efjA-2ykyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 SER A 287
GLN A 331
THR A 330
ILE A 101
HIS A 326
 None
 1.17A 2vdyA-2ykyA:
undetectable		 2vdyA-2ykyA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 6 TYR A 408
TYR A  82
PHE A 399
PRO A 411
 None
 1.31A 2vmyA-2ykyA:
22.4		 2vmyA-2ykyA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.36A 2wscA-2ykyA:
undetectable		 2wscA-2ykyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.36A 2wseA-2ykyA:
undetectable		 2wseA-2ykyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.35A 2wsfA-2ykyA:
undetectable		 2wsfA-2ykyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 6 ALA A 148
ALA A 152
THR A 155
PHE A 301
 None
 1.01A 2xfhA-2ykyA:
undetectable		 2xfhA-2ykyA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 8 GLN A 266
ILE A 271
ASP A 274
SER A 244
 None
 0.99A 2xytE-2ykyA:
undetectable		 2xytE-2ykyA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 145
GLY A 279
PHE A 141
PHE A 291
LEU A 177
 PLP  A1446 (-3.2A)
None
None
None
None
 1.18A 3dh0A-2ykyA:
undetectable		 3dh0A-2ykyA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 TYR A  89
GLY A 170
TYR A 172
GLU A 220
GLY A 226
 SFE  A1546 (-4.0A)
None
SFE  A1546 ( 3.7A)
PLP  A1446 (-3.9A)
None
 1.15A 3f8wA-2ykyA:
undetectable		 3f8wA-2ykyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 TYR A  89
GLY A 170
TYR A 172
GLU A 220
GLY A 226
 SFE  A1546 (-4.0A)
None
SFE  A1546 ( 3.7A)
PLP  A1446 (-3.9A)
None
 1.17A 3f8wB-2ykyA:
undetectable		 3f8wB-2ykyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		3 / 3 SER A 144
GLY A 145
THR A 146
 PLP  A1446 (-3.8A)
PLP  A1446 (-3.2A)
PLP  A1446 (-3.5A)
 0.23A 3k9wA-2ykyA:
undetectable		 3k9wA-2ykyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 5 TYR A 415
ILE A 437
LEU A 433
PHE A 429
 None
 1.19A 3ls4L-2ykyA:
undetectable		 3ls4L-2ykyA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.36A 3lw5A-2ykyA:
undetectable		 3lw5A-2ykyA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.24A 3pcqA-2ykyA:
undetectable		 3pcqA-2ykyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 8 GLY A  69
THR A  70
GLN A  75
GLN A  68
 None
 0.84A 3rglA-2ykyA:
undetectable		 3rglA-2ykyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 PHE A 133
LEU A 368
LEU A 269
MET A 268
TYR A 333
 None
SFE  A1447 (-4.9A)
SFE  A1447 ( 4.5A)
SFE  A1447 ( 4.2A)
None
 1.20A 3vn2A-2ykyA:
undetectable		 3vn2A-2ykyA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ASP A 169
ALA A 180
ASN A 178
ARG A 388
HIS A 375
 None
 1.49A 3w37A-2ykyA:
undetectable		 3w37A-2ykyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ASP A 169
ALA A 180
ASN A 178
ARG A 388
HIS A 375
 None
 1.49A 3welA-2ykyA:
undetectable		 3welA-2ykyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ASP A 169
ALA A 180
ASN A 178
ARG A 388
HIS A 375
 None
 1.50A 3weoA-2ykyA:
2.8		 3weoA-2ykyA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 SER A 287
GLN A 331
THR A 330
ILE A 101
HIS A 326
 None
 1.02A 4c49A-2ykyA:
undetectable		 4c49A-2ykyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 SER A 287
GLN A 331
THR A 330
ILE A 101
HIS A 326
 None
 1.19A 4c49B-2ykyA:
undetectable		 4c49B-2ykyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.26A 4fe1A-2ykyA:
undetectable
4fe1J-2ykyA:
undetectable		 4fe1A-2ykyA:
21.97
4fe1J-2ykyA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 6 ILE A  66
TYR A 408
TYR A  82
PHE A  74
 None
 1.12A 4g10A-2ykyA:
undetectable		 4g10A-2ykyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 285
MET A 286
ILE A 101
ARG A 132
LEU A 329
 None
 1.32A 4kovA-2ykyA:
undetectable		 4kovA-2ykyA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 8 GLY A 227
GLY A 413
ILE A 374
LEU A 409
 None
 0.76A 4mwzB-2ykyA:
undetectable		 4mwzB-2ykyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 LEU A 363
LEU A 443
LEU A 397
LEU A 433
PHE A 376
 None
 1.02A 4odoA-2ykyA:
undetectable		 4odoA-2ykyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 LEU A 363
LEU A 443
LEU A 397
LEU A 433
PHE A 376
 None
 1.03A 4odoB-2ykyA:
undetectable		 4odoB-2ykyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 LEU A 363
LEU A 443
LEU A 397
LEU A 433
PHE A 376
 None
 1.03A 4odoC-2ykyA:
undetectable		 4odoC-2ykyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 GLY A 171
GLY A 170
GLY A 224
ALA A 225
GLN A 266
 None
None
None
SFE  A1546 (-3.4A)
None
 1.05A 4rtmA-2ykyA:
undetectable		 4rtmA-2ykyA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 VAL A 192
LEU A 239
LEU A 153
LEU A 250
ILE A 251
 None
 1.31A 4ubsA-2ykyA:
undetectable		 4ubsA-2ykyA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 7 TYR A 415
PHE A 398
ALA A 432
LEU A 352
 None
 1.04A 4uymA-2ykyA:
undetectable		 4uymA-2ykyA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ASP A 435
HIS A 401
PHE A 376
ILE A 437
ALA A 356
 None
 1.34A 4wh5A-2ykyA:
undetectable		 4wh5A-2ykyA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 11 LEU A 239
GLY A 195
LEU A 194
LEU A 207
PHE A 179
 None
 1.11A 4wnuA-2ykyA:
undetectable		 4wnuA-2ykyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 8 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.26A 4xk8a-2ykyA:
undetectable		 4xk8a-2ykyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.29A 4y28A-2ykyA:
undetectable
4y28J-2ykyA:
0.0		 4y28A-2ykyA:
21.32
4y28J-2ykyA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		4 / 8 ILE A 282
GLY A 283
PHE A 301
CYH A 130
 None
 0.94A 5hieD-2ykyA:
undetectable		 5hieD-2ykyA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		3 / 3 SER A 383
LEU A 368
MET A 222
 None
SFE  A1447 (-4.9A)
None
 0.58A 5ikrB-2ykyA:
undetectable		 5ikrB-2ykyA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ILE A 217
THR A 257
GLU A 254
ALA A 156
SER A 135
 None
 1.15A 5iwuA-2ykyA:
undetectable		 5iwuA-2ykyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 9 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.29A 5l8rA-2ykyA:
undetectable		 5l8rA-2ykyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 PHE A 348
ARG A 259
ALA A 416
LEU A 417
GLY A 345
 None
 1.26A 5oy01-2ykyA:
undetectable
5oy07-2ykyA:
undetectable		 5oy01-2ykyA:
12.53
5oy07-2ykyA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 HIS A 311
VAL A 139
MET A 322
THR A 314
GLY A 313
 None
 1.26A 6brdA-2ykyA:
undetectable		 6brdA-2ykyA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 ASN A 351
PHE A 348
ASP A 423
GLY A 425
PHE A  85
 None
 1.35A 6dwnA-2ykyA:
undetectable		 6dwnA-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 12 LEU A 352
ASN A 351
PHE A 348
ASP A 423
PHE A  85
 None
 1.17A 6dwnB-2ykyA:
undetectable		 6dwnB-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		6 / 12 LEU A 352
ASN A 351
PHE A 348
ASP A 423
GLY A 425
PHE A  85
 None
 1.27A 6dwnC-2ykyA:
0.0		 6dwnC-2ykyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 10 GLU A 220
GLY A 171
ASN A 178
ALA A 180
GLY A 224
 PLP  A1446 (-3.9A)
None
None
None
None
 1.01A 6e5zA-2ykyA:
3.0		 6e5zA-2ykyA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2yky BETA-TRANSAMINASE
(Mesorhizobium
sp.
LUK) 		5 / 11 ALA A 148
ALA A 152
GLY A 175
GLY A 174
ASP A 253
 None
None
None
PLP  A1446 (-3.5A)
PLP  A1446 (-2.8A)
 0.91A 6hwdK-2ykyA:
undetectable
6hwdL-2ykyA:
undetectable		 6hwdK-2ykyA:
11.42
6hwdL-2ykyA:
11.82