SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 ILE A 513
ALA A 490
LEU A 494
ILE A 399
ILE A 408
 None
 1.04A 1dhiB-2yl2A:
undetectable		 1dhiB-2yl2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A 513
ALA A 490
LEU A 494
ILE A 399
ILE A 408
 None
 1.05A 1draB-2yl2A:
undetectable		 1draB-2yl2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 GLU A 602
ALA A 607
SER A 599
 None
 0.68A 1errB-2yl2A:
undetectable		 1errB-2yl2A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ASN A 643
ILE A 432
ASP A 414
ARG A 419
ILE A 645
 None
 1.37A 1q8jA-2yl2A:
undetectable		 1q8jA-2yl2A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 10 ILE A 513
ALA A 490
LEU A 494
ILE A 399
ILE A 408
 None
 1.03A 1rb3A-2yl2A:
undetectable		 1rb3A-2yl2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A 513
ALA A 490
LEU A 494
ILE A 399
ILE A 408
 None
 1.12A 1re7A-2yl2A:
undetectable		 1re7A-2yl2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 8 PRO A 269
VAL A 455
SER A 456
ALA A 502
 None
 1.13A 2v41G-2yl2A:
undetectable
2v41H-2yl2A:
undetectable		 2v41G-2yl2A:
17.19
2v41H-2yl2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 TRP A 246
VAL A 542
ARG A 604
 None
 0.94A 3b0wA-2yl2A:
undetectable		 3b0wA-2yl2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 ASN A 603
HIS A 541
VAL A 542
 None
 0.88A 3elzB-2yl2A:
0.9		 3elzB-2yl2A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		3 / 3 TYR A 224
TYR A 205
GLU A 197
 None
 0.83A 3pfgA-2yl2A:
undetectable		 3pfgA-2yl2A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 8 GLY A 352
GLY A 278
GLU A 251
TYR A 454
LEU A 475
 None
 1.19A 4fgzA-2yl2A:
undetectable		 4fgzA-2yl2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 11 GLY A 352
GLY A 353
GLY A 354
GLU A 474
GLN A 480
 None
 1.14A 4l8fB-2yl2A:
2.7		 4l8fB-2yl2A:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ASN A 476
ARG A 478
GLN A 480
VAL A 481
 None
 0.99A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 ASN A 476
ARG A 478
VAL A 481
GLU A 482
 None
 0.94A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		4 / 7 LYS A 423
ASN A 476
ARG A 478
GLN A 480
 None
 0.95A 4mv7A-2yl2A:
39.5		 4mv7A-2yl2A:
32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A 448
GLU A 474
VAL A 460
TRP A 297
GLY A 326
 None
 1.33A 4ydqA-2yl2A:
undetectable		 4ydqA-2yl2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 ILE A 513
ALA A 490
LEU A 494
ILE A 399
ILE A 408
 None
 1.08A 5e8qA-2yl2A:
undetectable		 5e8qA-2yl2A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 LEU A 448
GLY A 278
VAL A 460
TRP A 297
GLY A 326
 None
 1.32A 5f9zA-2yl2A:
undetectable		 5f9zA-2yl2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 10 ILE A 160
ILE A 237
ALA A 234
ILE A 233
ILE A 264
 None
 1.00A 5mvmD-2yl2A:
undetectable
5mvmE-2yl2A:
undetectable		 5mvmD-2yl2A:
9.81
5mvmE-2yl2A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		5 / 12 SER A 284
GLN A 320
THR A 294
SER A 300
GLY A 299
 None
 1.43A 5oj0A-2yl2A:
undetectable		 5oj0A-2yl2A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens) 		6 / 10 ILE A 425
ASN A 571
LEU A 631
LEU A 618
ALA A 614
GLU A 606
 None
 1.26A 5y7pG-2yl2A:
undetectable		 5y7pG-2yl2A:
20.84