SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ylk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A  46
GLN A  16
ARG A 101
 None
 0.93A 2w3bB-2ylkA:
undetectable		 2w3bB-2ylkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.65A 3aicA-2ylkA:
undetectable		 3aicA-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.65A 3aicB-2ylkA:
undetectable		 3aicB-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.67A 3aicE-2ylkA:
undetectable		 3aicE-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.70A 3aicF-2ylkA:
undetectable		 3aicF-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.67A 3aicG-2ylkA:
undetectable		 3aicG-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  34
TRP A 139
TYR A  32
 None
 0.66A 3aicH-2ylkA:
undetectable		 3aicH-2ylkA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 GLU A  46
ASP A 109
ASP A  74
 None
 0.67A 4gc9A-2ylkA:
undetectable		 4gc9A-2ylkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ARG A  40
ILE A 100
PHE A  43
LEU A  51
 None
 1.09A 4mmcA-2ylkA:
undetectable		 4mmcA-2ylkA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLU A  95
THR A 130
TYR A   6
PHE A 123
 None
 0.92A 5flcB-2ylkA:
undetectable		 5flcB-2ylkA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLU A  95
THR A 130
TYR A   6
PHE A 123
 None
 0.93A 5flcF-2ylkA:
undetectable		 5flcF-2ylkA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		3 / 3 HIS A 108
LYS A  45
PHE A  43
 None
 1.27A 5klaA-2ylkA:
undetectable		 5klaA-2ylkA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU A  39
THR A  93
ILE A  60
LEU A  34
 None
 0.74A 5te8C-2ylkA:
undetectable		 5te8C-2ylkA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 6 PRO A  88
GLY A  91
ASN A  26
LYS A   3
 None
 1.13A 5xxiA-2ylkA:
undetectable		 5xxiA-2ylkA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ILE A  18
PHE A  98
TYR A   6
THR A 119
 None
 1.16A 5z84N-2ylkA:
undetectable
5z84W-2ylkA:
undetectable		 5z84N-2ylkA:
14.74
5z84W-2ylkA:
15.17