SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 8 LEU A 188
ALA A 196
ILE A 154
VAL A 218
ILE A 191
 None
 1.34A 1d4yB-2ylnA:
undetectable		 1d4yB-2ylnA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 6 GLN A 115
ASP A  75
VAL A 112
GLY A 233
 None
 1.27A 1ekjC-2ylnA:
undetectable
1ekjD-2ylnA:
undetectable		 1ekjC-2ylnA:
24.58
1ekjD-2ylnA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 THR A 259
GLU A  77
ASP A  66
 None
 0.87A 1nt2A-2ylnA:
undetectable		 1nt2A-2ylnA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.44A 1v8bB-2ylnA:
undetectable		 1v8bB-2ylnA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 ALA A 113
THR A  79
PHE A 109
 None
 0.76A 2c6nB-2ylnA:
undetectable		 2c6nB-2ylnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 TYR A 133
ALA A 250
THR A  79
VAL A  78
ASN A 252
 None
 0.98A 2okcA-2ylnA:
undetectable		 2okcA-2ylnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 TYR A 133
ALA A 250
GLY A 258
VAL A  78
ASN A 252
 None
 1.12A 2okcB-2ylnA:
undetectable		 2okcB-2ylnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.35A 3g1uB-2ylnA:
undetectable		 3g1uB-2ylnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.33A 3g1uD-2ylnA:
undetectable		 3g1uD-2ylnA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 11 ILE A  45
PHE A 247
VAL A  90
VAL A  88
GLY A  87
 None
 0.84A 3kw4A-2ylnA:
undetectable		 3kw4A-2ylnA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 8 TYR A  74
PRO A 132
LEU A 260
ASP A 271
 None
GOL  A1283 (-4.5A)
None
None
 1.06A 3lsfH-2ylnA:
21.4		 3lsfH-2ylnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 6 GLY A 258
THR A 259
LEU A 263
ASP A 271
 None
 1.04A 3ps9A-2ylnA:
undetectable		 3ps9A-2ylnA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 PHE A 268
SER A 136
SER A 134
 None
 0.99A 3ufgB-2ylnA:
undetectable		 3ufgB-2ylnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 233
GLY A 231
VAL A 116
LEU A 118
SER A 130
 None
GOL  A1283 (-3.4A)
CYS  A 500 (-3.6A)
None
None
 0.87A 4f84A-2ylnA:
undetectable		 4f84A-2ylnA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 7 VAL A 181
SER A 165
GLN A 161
LEU A 184
 None
CYS  A 600 ( 4.1A)
None
CYS  A 600 (-4.3A)
 1.22A 4hxyB-2ylnA:
undetectable		 4hxyB-2ylnA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		4 / 7 VAL A  51
LEU A  41
SER A  40
GLU A  43
 None
 1.08A 4zphA-2ylnA:
undetectable
4zphB-2ylnA:
undetectable		 4zphA-2ylnA:
20.51
4zphB-2ylnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 9 THR A  79
VAL A  53
GLY A  54
THR A  55
VAL A  76
 None
 1.33A 5cp4A-2ylnA:
undetectable		 5cp4A-2ylnA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 GLY A 231
GLN A 115
LYS A 129
 GOL  A1283 (-3.4A)
None
GOL  A1283 (-2.7A)
 0.97A 5imsB-2ylnA:
undetectable		 5imsB-2ylnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		3 / 3 THR A 199
SER A 187
ASP A  98
 None
 0.81A 5kvaA-2ylnA:
undetectable		 5kvaA-2ylnA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.30A 5m5kB-2ylnA:
undetectable		 5m5kB-2ylnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID
(Neisseria
gonorrhoeae) 		5 / 12 LEU A  41
ASP A 110
THR A  52
GLY A  87
PHE A 247
 None
GOL  A1281 (-3.2A)
GOL  A1281 (-2.7A)
None
None
 1.37A 5m66A-2ylnA:
2.2		 5m66A-2ylnA:
22.27