SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ylz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 9 MET A 148
PHE A 433
SER A 150
GLY A 151
GLY A 436
 None
None
FAD  A 700 (-4.9A)
FAD  A 700 (-3.2A)
None
 1.12A 1jb0A-2ylzA:
undetectable		 1jb0A-2ylzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 8 SER A 196
ILE A  67
VAL A  54
SER A  27
 SO4  A1543 (-4.6A)
FAD  A 700 (-3.8A)
FAD  A 700 (-3.6A)
FAD  A 700 (-2.7A)
 1.11A 1kb9A-2ylzA:
undetectable
1kb9C-2ylzA:
undetectable
1kb9D-2ylzA:
undetectable
1kb9E-2ylzA:
undetectable		 1kb9A-2ylzA:
20.74
1kb9C-2ylzA:
21.49
1kb9D-2ylzA:
19.92
1kb9E-2ylzA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 ALA A 462
VAL A 457
TRP A 456
 None
 0.82A 1kqeA-2ylzA:
undetectable
1kqeE-2ylzA:
undetectable		 1kqeA-2ylzA:
10.47
1kqeE-2ylzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 ALA A 462
VAL A 457
TRP A 456
 None
 0.80A 1kqeB-2ylzA:
undetectable
1kqeD-2ylzA:
undetectable		 1kqeB-2ylzA:
10.47
1kqeD-2ylzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 TRP A 456
ALA A 462
VAL A 457
 None
 0.82A 1kqeB-2ylzA:
undetectable
1kqeD-2ylzA:
undetectable		 1kqeB-2ylzA:
10.47
1kqeD-2ylzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 TRP A 456
ALA A 462
VAL A 457
 None
 0.80A 1kqeA-2ylzA:
undetectable
1kqeE-2ylzA:
undetectable		 1kqeA-2ylzA:
10.47
1kqeE-2ylzA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 10 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.04A 1pxxA-2ylzA:
undetectable		 1pxxA-2ylzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 9 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.05A 1pxxB-2ylzA:
undetectable		 1pxxB-2ylzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.04A 1pxxC-2ylzA:
undetectable		 1pxxC-2ylzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 10 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.05A 1pxxD-2ylzA:
undetectable		 1pxxD-2ylzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ILE A 363
ALA A 361
PHE A 215
ARG A 188
LEU A 380
 None
 1.10A 1rx8A-2ylzA:
undetectable		 1rx8A-2ylzA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 GLN A 152
ALA A 442
GLY A 422
LEU A 421
LEU A 392
 FAD  A 700 (-3.4A)
None
None
None
None
 1.38A 2nv4B-2ylzA:
undetectable		 2nv4B-2ylzA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 ARG A 525
ASP A 459
ASP A 529
 None
 0.90A 3jayA-2ylzA:
undetectable		 3jayA-2ylzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 ARG A 525
ASP A 459
ASP A 529
 None
 0.90A 3jb3A-2ylzA:
undetectable		 3jb3A-2ylzA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 9 MET A 148
PHE A 433
SER A 150
GLY A 151
GLY A 436
 None
None
FAD  A 700 (-4.9A)
FAD  A 700 (-3.2A)
None
 1.12A 3pcqA-2ylzA:
undetectable		 3pcqA-2ylzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 ASN A 445
GLU A  71
ARG A 246
 None
 0.95A 3wxoA-2ylzA:
undetectable		 3wxoA-2ylzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.04A 4coxC-2ylzA:
undetectable		 4coxC-2ylzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 11 MET A 148
PHE A 433
SER A 150
GLY A 151
GLY A 436
 None
None
FAD  A 700 (-4.9A)
FAD  A 700 (-3.2A)
None
 1.23A 4l6v1-2ylzA:
undetectable
4l6v6-2ylzA:
undetectable		 4l6v1-2ylzA:
22.21
4l6v6-2ylzA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 6 ARG A 337
ASP A  66
PRO A 286
ARG A 258
 FAD  A 700 (-3.3A)
FAD  A 700 (-4.1A)
None
None
 1.22A 4lajA-2ylzA:
undetectable
4lajB-2ylzA:
undetectable		 4lajA-2ylzA:
21.22
4lajB-2ylzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 4 LYS A 165
ASN A 170
ASP A 381
ASP A 166
 None
 1.47A 4o1eB-2ylzA:
undetectable		 4o1eB-2ylzA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ASN A  58
GLY A 198
SER A 196
ILE A 192
GLY A 190
 FAD  A 700 (-4.2A)
None
SO4  A1543 (-4.6A)
None
None
 1.06A 4obwA-2ylzA:
undetectable		 4obwA-2ylzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ASN A  58
GLY A 198
SER A 196
ILE A 192
GLY A 190
 FAD  A 700 (-4.2A)
None
SO4  A1543 (-4.6A)
None
None
 1.07A 4obwC-2ylzA:
undetectable		 4obwC-2ylzA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.06A 4otyA-2ylzA:
undetectable		 4otyA-2ylzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.07A 4otyB-2ylzA:
undetectable		 4otyB-2ylzA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 TYR A  90
GLY A 285
PRO A 286
 None
 0.68A 4qwpA-2ylzA:
1.7		 4qwpA-2ylzA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.13A 4rrwA-2ylzA:
undetectable		 4rrwA-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.13A 4rrwB-2ylzA:
undetectable		 4rrwB-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.07A 4rrwD-2ylzA:
undetectable		 4rrwD-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.13A 4rrzA-2ylzA:
undetectable		 4rrzA-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.13A 4rrzB-2ylzA:
undetectable		 4rrzB-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.07A 4rrzD-2ylzA:
undetectable		 4rrzD-2ylzA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 8 MET A 148
PHE A 433
SER A 150
GLY A 436
 None
None
FAD  A 700 (-4.9A)
None
 1.00A 4xk8a-2ylzA:
undetectable		 4xk8a-2ylzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 SER A 374
PHE A 215
GLU A 364
LEU A 383
GLY A 163
 None
 1.44A 4zjlA-2ylzA:
1.0		 4zjlA-2ylzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 5 SER A 441
GLY A  25
THR A  47
GLU A  46
 None
FAD  A 700 (-3.4A)
FAD  A 700 (-4.3A)
FAD  A 700 (-2.7A)
 1.18A 5btiA-2ylzA:
undetectable
5btiB-2ylzA:
undetectable		 5btiA-2ylzA:
23.13
5btiB-2ylzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 5 SER A 441
GLY A  25
THR A  47
GLU A  46
 None
FAD  A 700 (-3.4A)
FAD  A 700 (-4.3A)
FAD  A 700 (-2.7A)
 1.20A 5btiC-2ylzA:
undetectable
5btiD-2ylzA:
undetectable		 5btiC-2ylzA:
23.13
5btiD-2ylzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 PHE A  76
SER A  77
GLU A  79
VAL A  80
SER A 111
 None
 1.30A 5f9zB-2ylzA:
undetectable		 5f9zB-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.10A 5ikqA-2ylzA:
undetectable		 5ikqA-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 LEU A 146
VAL A  21
GLY A  23
ALA A 149
SER A 150
 None
None
FAD  A 700 (-3.3A)
None
FAD  A 700 (-4.9A)
 1.10A 5ikqB-2ylzA:
undetectable		 5ikqB-2ylzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 9 MET A 148
PHE A 433
SER A 150
GLY A 151
GLY A 436
 None
None
FAD  A 700 (-4.9A)
FAD  A 700 (-3.2A)
None
 1.14A 5l8rA-2ylzA:
undetectable		 5l8rA-2ylzA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ILE A 199
GLY A 198
VAL A 214
PHE A 348
ALA A 222
 None
 1.12A 5n0oA-2ylzA:
undetectable		 5n0oA-2ylzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ILE A 199
GLY A 198
VAL A 214
PHE A 348
ALA A 222
 None
 1.12A 5n0rA-2ylzA:
undetectable		 5n0rA-2ylzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		5 / 12 ILE A 199
GLY A 198
VAL A 214
PHE A 348
ALA A 222
 None
 1.11A 5n0wA-2ylzA:
undetectable		 5n0wA-2ylzA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		3 / 3 GLU A  68
ARG A  89
TYR A  90
 None
 0.58A 5trqB-2ylzA:
undetectable		 5trqB-2ylzA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 2ylz PHENYLACETONE
MONOOXYGENASE
(Thermobifida
fusca) 		4 / 5 SER A 449
VAL A 448
ASN A 445
PRO A 253
 None
 1.40A 6fi4A-2ylzA:
undetectable
6fi4B-2ylzA:
undetectable		 6fi4A-2ylzA:
19.08
6fi4B-2ylzA:
14.81