SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ymb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 152
ILE A 120
LEU A 141
 None
 0.69A 2kceA-2ymbA:
undetectable		 2kceA-2ymbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PRO A 123
ILE A 125
ARG A 126
ASP A 212
 None
 1.44A 2rhmD-2ymbA:
undetectable		 2rhmD-2ymbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 ILE A  94
THR A 236
GLY A 208
GLY A 210
PHE A 107
 None
 1.27A 4bwlC-2ymbA:
undetectable		 4bwlC-2ymbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 141
PHE A 199
ILE A 151
ILE A 192
ILE A 197
 None
 1.17A 5y2tB-2ymbA:
undetectable		 5y2tB-2ymbA:
undetectable