SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 11 THR B 145
VAL B 181
LEU D 270
ALA D 260
VAL D 258
 None
 1.17A 1rv7A-2ymsB:
undetectable
1rv7B-2ymsB:
undetectable		 1rv7A-2ymsB:
21.78
1rv7B-2ymsB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 113
LEU A  97
VAL A  95
SER A 126
ALA A 151
 None
 1.04A 2vmyA-2ymsA:
undetectable		 2vmyA-2ymsA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli;
Escherichia
coli) 		5 / 12 GLY A  89
ASP A  88
ARG D 295
ALA D 307
ALA A  83
 None
 1.09A 3g8bB-2ymsA:
undetectable		 3g8bB-2ymsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_B_017B203_1
(PROTEASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		4 / 5 PRO A  65
LYS A  62
ARG A 154
GLY A 113
 None
 1.27A 3s53B-2ymsA:
0.0		 3s53B-2ymsA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli;
Escherichia
coli) 		3 / 3 LYS A  62
SER D 285
GLN D 301
 None
 1.14A 3si7A-2ymsA:
undetectable		 3si7A-2ymsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli;
Escherichia
coli) 		3 / 3 SER A  96
ASP D 303
ASP D 288
 None
 0.70A 3uj7A-2ymsA:
undetectable		 3uj7A-2ymsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 LEU D 270
ASP D 271
VAL D 258
SER B 158
LEU B 174
 None
 1.22A 4iarA-2ymsD:
undetectable		 4iarA-2ymsD:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 PHE D 259
ALA D 269
ARG D 281
VAL D 305
LEU D 308
 None
 1.29A 4qzuA-2ymsD:
undetectable		 4qzuA-2ymsD:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		4 / 8 ALA A 133
VAL A 131
VAL A 157
HIS A 121
 None
 0.62A 5ecnD-2ymsA:
undetectable		 5ecnD-2ymsA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		4 / 8 ALA B 133
VAL B 131
VAL B 157
HIS B 121
 None
 0.62A 5ecnD-2ymsB:
undetectable		 5ecnD-2ymsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.01A 5wz1A-2ymsA:
undetectable		 5wz1A-2ymsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.03A 5wz1C-2ymsA:
undetectable		 5wz1C-2ymsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.00A 5wz1D-2ymsA:
undetectable		 5wz1D-2ymsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.00A 5wz1F-2ymsA:
undetectable		 5wz1F-2ymsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.01A 5wz1G-2ymsA:
undetectable		 5wz1G-2ymsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2yms OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 113
LYS A  62
GLU A 127
ILE A 124
 None
 1.00A 5wz1H-2ymsA:
undetectable		 5wz1H-2ymsA:
21.30