SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ymz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2ymz GALECTIN 2
(Gallus
gallus) 		5 / 12 PHE A  76
ILE A  33
VAL A  86
VAL A 103
ILE A  55
 None
 1.19A 1r5lA-2ymzA:
undetectable		 1r5lA-2ymzA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 6 HIS A  45
ASN A  47
ASN A  58
TRP A  65
 None
 0.28A 3galA-2ymzA:
20.7		 3galA-2ymzA:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 6 HIS A  45
ASN A  47
ASN A  58
TRP A  65
 None
 0.29A 3galB-2ymzA:
20.3		 3galB-2ymzA:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 7 LEU A  60
ASP A  63
SER A  40
TYR A 111
 None
 1.19A 4arcA-2ymzA:
undetectable		 4arcA-2ymzA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA503_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 6 SER A  80
TYR A  77
PHE A  76
PHE A  74
 None
 1.22A 4awuA-2ymzA:
undetectable		 4awuA-2ymzA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ymz GALECTIN 2
(Gallus
gallus) 		5 / 11 ILE A  33
TRP A  65
LEU A  42
LEU A 117
CYH A  57
 None
 1.11A 5ji0A-2ymzA:
undetectable		 5ji0A-2ymzA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 4 LEU A 117
ARG A   3
ILE A 119
PHE A   5
 None
 1.35A 5kirB-2ymzA:
undetectable		 5kirB-2ymzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 7 GLY A 121
PHE A  31
SER A  25
ASN A 118
 None
None
SO4  A1132 ( 3.9A)
None
 1.01A 5n5dB-2ymzA:
undetectable		 5n5dB-2ymzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2ymz GALECTIN 2
(Gallus
gallus) 		5 / 7 HIS A  45
ASN A  47
ASN A  58
TRP A  65
ARG A  70
 None
 0.29A 6b8kA-2ymzA:
20.2		 6b8kA-2ymzA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 2ymz GALECTIN 2
(Gallus
gallus) 		5 / 8 HIS A  45
ASN A  47
ASN A  58
TRP A  65
ARG A  70
 None
 0.46A 6b94A-2ymzA:
24.1		 6b94A-2ymzA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 2ymz GALECTIN 2
(Gallus
gallus) 		5 / 10 HIS A  45
ASN A  47
ASN A  58
TRP A  65
ARG A  70
 None
 0.36A 6b94A-2ymzA:
24.1
6b94B-2ymzA:
23.9		 6b94A-2ymzA:
28.35
6b94B-2ymzA:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 8 TRP A  65
HIS A  45
ARG A  70
GLU A  52
 None
 1.22A 6mn4D-2ymzA:
undetectable		 6mn4D-2ymzA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ymz GALECTIN 2
(Gallus
gallus) 		4 / 7 TRP A  65
HIS A  45
ARG A  70
GLU A  52
 None
 1.37A 6mn4F-2ymzA:
undetectable		 6mn4F-2ymzA:
18.95