SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 246
ALA A   9
GLY A 242
MET A 240
LEU A 176
 None
 1.37A 1brpA-2yn0A:
undetectable		 1brpA-2yn0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 118
TYR A 108
GLY A 117
PRO A 116
GLU A  71
 None
 1.45A 1equA-2yn0A:
undetectable		 1equA-2yn0A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 127
GLY A  89
LEU A 176
TYR A 140
PHE A 257
 None
 1.35A 1pj7A-2yn0A:
undetectable		 1pj7A-2yn0A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  82
PRO A  83
PHE A  62
VAL A 161
 None
 1.29A 2hjhB-2yn0A:
undetectable		 2hjhB-2yn0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 241
ARG A 198
ASP A 258
 None
 0.91A 2qe6A-2yn0A:
2.1		 2qe6A-2yn0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 241
ARG A 198
ASP A 258
 None
 0.98A 2qe6B-2yn0A:
undetectable		 2qe6B-2yn0A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  76
ALA A  44
LEU A 247
LEU A  54
THR A  72
 None
 1.21A 2w3mB-2yn0A:
3.3		 2w3mB-2yn0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 THR A 244
SER A 199
LYS A 173
 None
 1.11A 3aocC-2yn0A:
undetectable		 3aocC-2yn0A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 134
PHE A 257
ARG A 142
PHE A 143
 None
 0.91A 3mjrD-2yn0A:
undetectable		 3mjrD-2yn0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 THR A 244
ASN A 243
ASP A 205
ILE A 197
 None
 1.26A 3w9tB-2yn0A:
undetectable		 3w9tB-2yn0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  70
VAL A 118
ALA A  77
GLU A  87
ALA A  63
 None
 1.30A 4fiaA-2yn0A:
undetectable		 4fiaA-2yn0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  70
VAL A 118
ALA A  77
GLU A  87
ALA A  63
 None
 1.30A 4fiaA-2yn0A:
undetectable		 4fiaA-2yn0A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 ILE A   8
PHE A 146
LEU A 176
PHE A 231
 None
 0.94A 4qopC-2yn0A:
undetectable		 4qopC-2yn0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASP A  31
PRO A 103
TYR A  94
SER A  15
 None
 1.20A 5l1fC-2yn0A:
3.1		 5l1fC-2yn0A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 198
GLY A 242
THR A 244
GLU A 251
 None
 1.11A 5ny7A-2yn0A:
undetectable		 5ny7A-2yn0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2yn0 TRANSCRIPTION FACTOR
TAU 55 KDA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 180
ILE A 151
PHE A 150
VAL A   3
ILE A   6
 None
 1.27A 6ef6A-2yn0A:
undetectable		 6ef6A-2yn0A:
20.44