SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 10 LEU A  16
ILE A  71
THR A  65
LYS A  68
THR A  88
 None
None
None
None
PGE  A1107 ( 4.9A)
 1.48A 1tw4B-2yn1A:
undetectable		 1tw4B-2yn1A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ASP A  25
LEU A  77
TYR A  48
ILE A  40
SER A  96
 None
 1.38A 1xmuA-2yn1A:
undetectable		 1xmuA-2yn1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ASP A  25
LEU A  77
TYR A  48
ILE A  40
SER A  96
 None
 1.32A 1xmuB-2yn1A:
undetectable		 1xmuB-2yn1A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 10 ALA A  45
LEU A  93
LEU A  77
LEU A  41
LEU A  98
 None
 1.19A 2riwA-2yn1A:
undetectable
2riwB-2yn1A:
undetectable		 2riwA-2yn1A:
17.37
2riwB-2yn1A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 10 ALA A  45
LEU A  93
LEU A  77
LEU A  41
LEU A  98
 None
 1.14A 2xn6A-2yn1A:
undetectable
2xn6B-2yn1A:
undetectable		 2xn6A-2yn1A:
16.62
2xn6B-2yn1A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		4 / 7 PHE A 101
LEU A  79
LEU A  52
LEU A  23
 None
 0.86A 3bgdB-2yn1A:
undetectable		 3bgdB-2yn1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 11 LEU A 102
LEU A  23
LEU A  98
GLU A  43
LEU A  41
 None
 1.07A 4wg0F-2yn1A:
undetectable
4wg0G-2yn1A:
undetectable
4wg0H-2yn1A:
undetectable		 4wg0F-2yn1A:
7.55
4wg0G-2yn1A:
7.55
4wg0H-2yn1A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.08A 5n0sA-2yn1A:
undetectable		 5n0sA-2yn1A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.08A 5n0sB-2yn1A:
undetectable		 5n0sB-2yn1A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.05A 5n0tA-2yn1A:
undetectable		 5n0tA-2yn1A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		5 / 12 ILE A   3
VAL A  57
PHE A  26
ILE A  44
ALA A  45
 None
 1.07A 5n4iA-2yn1A:
undetectable		 5n4iA-2yn1A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		4 / 7 VAL A   6
ILE A   4
VAL A  24
ALA A  55
 None
 0.67A 5ospA-2yn1A:
undetectable		 5ospA-2yn1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 2yn1 LGPCA THIOREDOXIN
(synthetic
construct) 		4 / 7 VAL A   6
ILE A   4
VAL A  24
ALA A  55
 None
 0.68A 5osrA-2yn1A:
undetectable		 5osrA-2yn1A:
17.11