SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 169
TRP A 242
PHE A 244
GLU A 249
 FMT  A1264 (-3.4A)
None
None
None
 1.06A 1dmiA-2yn2A:
undetectable
1dmiB-2yn2A:
undetectable		 1dmiA-2yn2A:
20.00
1dmiB-2yn2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		5 / 10 THR A 167
GLY A  91
ALA A 170
ALA A 174
ILE A 138
 None
 1.08A 1likA-2yn2A:
undetectable		 1likA-2yn2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  82
PRO A  83
PHE A  62
VAL A 160
 None
 1.45A 2hjhB-2yn2A:
undetectable		 2hjhB-2yn2A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  41
GLU A  38
GLU A  42
 None
 0.76A 2nv4A-2yn2A:
undetectable		 2nv4A-2yn2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		3 / 3 ILE A   8
ILE A 196
LEU A  54
 None
 0.53A 2prgA-2yn2A:
undetectable		 2prgA-2yn2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  14
VAL A  90
THR A 171
 FMT  A1264 (-4.0A)
None
None
 0.85A 3cyxA-2yn2A:
undetectable		 3cyxA-2yn2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 8 ALA A   9
GLY A  12
PRO A  75
THR A  76
 None
 0.74A 3el9A-2yn2A:
undetectable		 3el9A-2yn2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		5 / 12 GLN A  43
HIS A  39
GLY A  40
GLY A 251
GLU A 249
 None
None
None
FMT  A1264 ( 3.7A)
None
 1.14A 3v3oB-2yn2A:
undetectable		 3v3oB-2yn2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 6 GLU A  92
ASP A  31
ASP A 255
ASN A  16
 FMT  A1264 (-3.2A)
None
None
None
 1.00A 3vywA-2yn2A:
undetectable		 3vywA-2yn2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 5 GLU A  92
ASP A  31
ASP A 255
ASN A  16
 FMT  A1264 (-3.2A)
None
None
None
 1.02A 3vywD-2yn2A:
undetectable		 3vywD-2yn2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 6 THR A 231
ASN A 230
ASP A 204
ILE A 196
 None
 1.28A 3w9tB-2yn2A:
undetectable		 3w9tB-2yn2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		5 / 11 GLN A  43
HIS A  39
GLY A  40
GLY A 251
GLU A 249
 None
None
None
FMT  A1264 ( 3.7A)
None
 1.13A 4a6nB-2yn2A:
0.0		 4a6nB-2yn2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		3 / 3 ARG A  68
TRP A  17
GLY A 251
 None
None
FMT  A1264 ( 3.7A)
 0.58A 4e7cA-2yn2A:
undetectable		 4e7cA-2yn2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		3 / 3 SER A  37
TYR A  13
PRO A  24
 None
 0.98A 4kanB-2yn2A:
undetectable		 4kanB-2yn2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 8 ILE A   8
PHE A 145
LEU A 175
PHE A 218
 None
 0.91A 4qopC-2yn2A:
undetectable		 4qopC-2yn2A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		4 / 6 TRP A  17
LEU A 234
THR A  72
VAL A 166
 None
 1.10A 4udaA-2yn2A:
undetectable		 4udaA-2yn2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2yn2 UNCHARACTERIZED
PROTEIN YNL108C
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  47
ALA A  48
THR A 162
VAL A 166
ALA A   9
 None
 1.02A 4x20B-2yn2A:
undetectable		 4x20B-2yn2A:
22.62