SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 5 LEU A 368
MET A 302
LEU A 301
GLN A 364
 None
 1.40A 1p93D-2yn7A:
undetectable		 1p93D-2yn7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 8 ILE A 323
ILE A 319
ASN A 352
ALA A 406
 None
 0.71A 2nniA-2yn7A:
2.1		 2nniA-2yn7A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 PHE A 281
SER A 376
ASN A 371
GLY A 367
ALA A 365
 None
 1.47A 2x2iB-2yn7A:
undetectable		 2x2iB-2yn7A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 12 MET A 285
ILE A 284
LEU A 288
LEU A 393
ALA A 365
 None
 1.04A 3a50D-2yn7A:
undetectable		 3a50D-2yn7A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 6 HIS A 295
ASN A 292
ASN A 294
GLU A 291
 None
 1.27A 3galA-2yn7A:
undetectable		 3galA-2yn7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 6 HIS A 295
ASN A 292
ASN A 294
GLU A 291
 None
 1.27A 3galB-2yn7A:
undetectable		 3galB-2yn7A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 12 ALA A 269
GLU A 313
ILE A 310
LEU A 253
THR A 213
 None
 1.23A 4cd2A-2yn7A:
undetectable		 4cd2A-2yn7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 LEU A 393
ALA A 232
GLU A 300
PHE A 281
LEU A 368
 None
 1.49A 4la0A-2yn7A:
2.1		 4la0A-2yn7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		5 / 10 TYR A 392
LEU A 288
LEU A 384
GLY A 282
MET A 285
 None
 1.47A 4zp0A-2yn7A:
2.2		 4zp0A-2yn7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 5ewzB-2yn7A:
3.1		 5ewzB-2yn7A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.78A 5m35B-2yn7A:
3.2		 5m35B-2yn7A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 5m36A-2yn7A:
3.7		 5m36A-2yn7A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		4 / 7 HIS A 295
ASN A 292
ASN A 294
GLU A 291
 None
 1.29A 6b8kA-2yn7A:
undetectable		 6b8kA-2yn7A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 GLN A 364
TYR A 392
ASN A 395
 None
 0.90A 6dwdC-2yn7A:
undetectable		 6dwdC-2yn7A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 6fn9A-2yn7A:
3.4		 6fn9A-2yn7A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 6fnaB-2yn7A:
undetectable		 6fnaB-2yn7A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2yn7 OUTER SURFACE
PROTEIN
(Borreliella
burgdorferi) 		3 / 3 MET A 396
GLN A 397
ARG A 400
 None
 0.80A 6fnbA-2yn7A:
undetectable		 6fnbA-2yn7A:
25.94