SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yne'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 8 LEU A 409
VAL A 405
LEU A 277
ALA A 279
 None
None
None
DMS  A 999 ( 4.6A)
 0.92A 1fiqC-2yneA:
0.4		 1fiqC-2yneA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xA-2yneA:
undetectable		 1h7xA-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.25A 1h7xB-2yneA:
undetectable		 1h7xB-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xC-2yneA:
undetectable		 1h7xC-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 ILE A  52
ASN A  55
ASN A 187
THR A 183
 None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
 1.24A 1h7xD-2yneA:
undetectable		 1h7xD-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 PRO A 205
LYS A 389
ALA A 209
GLU A 368
 None
 1.24A 1qhyA-2yneA:
undetectable		 1qhyA-2yneA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 PRO A  68
LEU A 137
ILE A 138
SER A 134
 None
 1.03A 1sbrA-2yneA:
undetectable
1sbrB-2yneA:
undetectable		 1sbrA-2yneA:
18.44
1sbrB-2yneA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 5 LEU A 116
ARG A  84
ALA A 115
ILE A  87
 None
 0.95A 2qhfA-2yneA:
undetectable		 2qhfA-2yneA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 9 TYR A 315
LEU A  91
LEU A 112
ALA A 115
PHE A 162
 None
 1.25A 2vcvH-2yneA:
undetectable		 2vcvH-2yneA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 9 TYR A 315
LEU A  91
LEU A 112
ALA A 115
PHE A 162
 None
 1.20A 2vcvI-2yneA:
undetectable		 2vcvI-2yneA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 7 LEU A 317
VAL A  96
LEU A 388
LEU A 116
 None
NHW  A1000 ( 4.0A)
YNE  A1001 (-4.2A)
None
 0.92A 3g8iA-2yneA:
undetectable		 3g8iA-2yneA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 MET A 256
PRO A 292
ILE A 286
VAL A 264
VAL A 301
 None
 1.24A 3iw1A-2yneA:
undetectable		 3iw1A-2yneA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 11 LEU A 379
PHE A 381
ILE A 353
ALA A 366
ALA A 352
 None
 1.13A 3mdtB-2yneA:
undetectable		 3mdtB-2yneA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.00A 3mteB-2yneA:
undetectable		 3mteB-2yneA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 GLY A 139
GLY A 128
LEU A 163
THR A  89
LEU A  90
 None
None
NHW  A1000 (-4.1A)
None
None
 1.01A 3p2kB-2yneA:
undetectable		 3p2kB-2yneA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 5 PHE A 140
TYR A 107
LEU A 169
ARG A 104
 None
 1.19A 3sudD-2yneA:
undetectable		 3sudD-2yneA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 LEU A 392
ALA A 279
THR A 146
LEU A 409
 None
DMS  A 999 ( 4.6A)
DMS  A 999 ( 4.8A)
None
 0.95A 3t3zA-2yneA:
undetectable		 3t3zA-2yneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 LEU A 392
ALA A 279
THR A 146
LEU A 409
 None
DMS  A 999 ( 4.6A)
DMS  A 999 ( 4.8A)
None
 0.94A 3t3zB-2yneA:
undetectable		 3t3zB-2yneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 LEU A 392
ALA A 279
THR A 146
LEU A 409
 None
DMS  A 999 ( 4.6A)
DMS  A 999 ( 4.8A)
None
 1.00A 3t3zD-2yneA:
undetectable		 3t3zD-2yneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 8 LEU A 409
VAL A 405
LEU A 277
ALA A 279
 None
None
None
DMS  A 999 ( 4.6A)
 0.94A 3uniB-2yneA:
undetectable		 3uniB-2yneA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 ILE A 144
ILE A 407
VAL A 405
LEU A 277
VAL A 206
 None
 1.23A 3w68C-2yneA:
undetectable		 3w68C-2yneA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 PHE A 290
MET A 256
ILE A 286
VAL A 339
 None
 1.23A 4mk4B-2yneA:
undetectable		 4mk4B-2yneA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 8 PHE A 336
TRP A 114
ASN A 161
ILE A 148
 None
None
NHW  A1000 (-4.6A)
None
 0.85A 4qoiA-2yneA:
undetectable
4qoiB-2yneA:
undetectable		 4qoiA-2yneA:
20.41
4qoiB-2yneA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 6 TYR A 315
TYR A 107
LEU A 112
PHE A 162
 None
 1.14A 4twdI-2yneA:
undetectable
4twdJ-2yneA:
undetectable		 4twdI-2yneA:
24.51
4twdJ-2yneA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 10 PHE A 103
VAL A 363
ASP A 362
PHE A 226
SER A 319
 None
None
None
None
YNE  A1001 (-3.5A)
 1.06A 4xp1A-2yneA:
undetectable		 4xp1A-2yneA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 11 PHE A 103
VAL A 363
ASP A 362
PHE A 226
SER A 319
 None
None
None
None
YNE  A1001 (-3.5A)
 1.16A 4xp4A-2yneA:
undetectable		 4xp4A-2yneA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		4 / 7 PHE A 103
ASP A  98
ILE A 102
GLY A 225
 None
 0.95A 4zxiA-2yneA:
undetectable		 4zxiA-2yneA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE
(Plasmodium
vivax) 		5 / 12 LEU A  67
GLY A 128
TYR A  95
ILE A 138
LEU A 116
 None
None
NHW  A1000 (-4.3A)
None
None
 1.03A 5ycnA-2yneA:
undetectable		 5ycnA-2yneA:
21.09