SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ynp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 SER A 154
THR A 155
PHE A 136
GLY A 171
 None
 1.12A 1icuA-2ynpA:
undetectable
1icuB-2ynpA:
undetectable		 1icuA-2ynpA:
17.00
1icuB-2ynpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.06A 1icuA-2ynpA:
undetectable
1icuB-2ynpA:
undetectable		 1icuA-2ynpA:
17.00
1icuB-2ynpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 SER A 154
THR A 155
PHE A 136
GLY A 171
 None
 1.12A 1icuC-2ynpA:
undetectable
1icuD-2ynpA:
undetectable		 1icuC-2ynpA:
17.00
1icuD-2ynpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.10A 1icuC-2ynpA:
undetectable
1icuD-2ynpA:
undetectable		 1icuC-2ynpA:
17.00
1icuD-2ynpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 136
GLY A 171
SER A 154
THR A 155
 None
 1.02A 1icvA-2ynpA:
undetectable
1icvB-2ynpA:
undetectable		 1icvA-2ynpA:
17.00
1icvB-2ynpA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 SER A 154
THR A 155
PHE A 136
GLY A 171
 None
 1.14A 1kqbC-2ynpA:
undetectable
1kqbD-2ynpA:
undetectable		 1kqbC-2ynpA:
16.69
1kqbD-2ynpA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  71
TRP A 124
LEU A 123
TRP A 130
 None
 1.27A 1q0yH-2ynpA:
undetectable
1q0yL-2ynpA:
undetectable		 1q0yH-2ynpA:
18.43
1q0yL-2ynpA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 LYS A   2
ILE A 254
THR A 259
 None
 0.83A 1rx3A-2ynpA:
undetectable		 1rx3A-2ynpA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 501
LEU A 482
SER A 477
 None
 0.64A 1tlmA-2ynpA:
undetectable		 1tlmA-2ynpA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 421
SER A 406
TYR A 418
ASN A 367
 None
 1.18A 2wekA-2ynpA:
undetectable		 2wekA-2ynpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 421
SER A 406
TYR A 418
ASN A 367
 None
 1.21A 2wekB-2ynpA:
undetectable		 2wekB-2ynpA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 396
ILE A 410
ASP A 437
SER A 449
 None
 1.21A 2xytI-2ynpA:
undetectable		 2xytI-2ynpA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 352
ASP A 356
ILE A 381
VAL A 316
ILE A 328
 None
 0.90A 3el1A-2ynpA:
undetectable		 3el1A-2ynpA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 226
ILE A 210
VAL A 262
SER A 245
 None
 1.26A 4d33A-2ynpA:
undetectable		 4d33A-2ynpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 226
ILE A 210
VAL A 262
SER A 245
 None
 1.24A 4d33B-2ynpA:
undetectable		 4d33B-2ynpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 389
LEU A 352
PHE A 370
 None
 0.79A 4dajB-2ynpA:
undetectable		 4dajB-2ynpA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  20
LEU A  39
VAL A  53
 None
 0.71A 4jecB-2ynpA:
undetectable		 4jecB-2ynpA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 301
ILE A 254
PRO A 241
LEU A 300
LEU A   3
 None
 1.07A 4xj7A-2ynpA:
undetectable
4xj7B-2ynpA:
undetectable		 4xj7A-2ynpA:
20.20
4xj7B-2ynpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 300
LEU A   3
GLY A 301
ILE A 254
PRO A 241
 None
 1.12A 4xj7C-2ynpA:
undetectable
4xj7D-2ynpA:
undetectable		 4xj7C-2ynpA:
20.20
4xj7D-2ynpA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 455
ILE A 467
ASP A 523
 None
 0.66A 5cswA-2ynpA:
undetectable		 5cswA-2ynpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 455
ILE A 467
ASP A 523
 None
 0.74A 5cswB-2ynpA:
undetectable		 5cswB-2ynpA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 183
THR A 209
ASP A 207
 None
 0.86A 5k9dA-2ynpA:
undetectable		 5k9dA-2ynpA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 132
ASP A  92
SER A 114
ILE A 100
ARG A  80
 None
 1.26A 5uhgC-2ynpA:
0.0		 5uhgC-2ynpA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 2ynp COATOMER SUBUNIT
BETA'
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 292
ASN A 267
LEU A 252
PHE A 233
 None
 1.02A 6ekuA-2ynpA:
8.5		 6ekuA-2ynpA:
22.58