SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ynt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 SER B  57
ASP B  91
SER B  69
VAL B  67
 None
 1.13A 2hdnI-2yntB:
undetectable
2hdnJ-2yntB:
undetectable
2hdnL-2yntB:
undetectable		 2hdnI-2yntB:
9.44
2hdnJ-2yntB:
21.20
2hdnL-2yntB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 SER B  69
VAL B  67
SER B  57
ASP B  91
 None
 1.12A 2hdnJ-2yntB:
undetectable
2hdnK-2yntB:
undetectable
2hdnL-2yntB:
undetectable		 2hdnJ-2yntB:
21.20
2hdnK-2yntB:
9.44
2hdnL-2yntB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 10 GLY B 195
ILE B 249
VAL B 202
GLY B 220
ILE B 246
 None
 0.85A 3s43B-2yntB:
undetectable		 3s43B-2yntB:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		6 / 9 TRP B  87
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.28A 4c1dA-2yntB:
34.0		 4c1dA-2yntB:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		7 / 10 TRP B  87
HIS B 116
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1297 (-3.2A)
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.31A 4c1dB-2yntB:
33.8		 4c1dB-2yntB:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		6 / 11 HIS B 116
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 ZN  B1297 (-3.2A)
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.39A 4c1fA-2yntB:
35.7
4c1fB-2yntB:
35.4		 4c1fA-2yntB:
44.40
4c1fB-2yntB:
44.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 VAL B  67
HIS B 116
ASP B 120
HIS B 196
CYH B 221
 None
ZN  B1297 (-3.2A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
 1.33A 4c1fA-2yntB:
35.7
4c1fB-2yntB:
35.4		 4c1fA-2yntB:
44.40
4c1fB-2yntB:
44.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		7 / 9 HIS B 116
HIS B 118
ASP B 120
HIS B 196
CYH B 221
GLY B 232
HIS B 263
 ZN  B1297 (-3.2A)
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
None
ZN  B1298 (-3.2A)
 0.50A 4c1hA-2yntB:
33.2		 4c1hA-2yntB:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		7 / 9 TRP B  87
HIS B 116
ASP B 120
HIS B 196
CYH B 221
GLY B 232
HIS B 263
 None
ZN  B1297 (-3.2A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
None
ZN  B1298 (-3.2A)
 0.90A 4c1hA-2yntB:
33.2		 4c1hA-2yntB:
40.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 9 TRP B  87
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 1.01A 4exsA-2yntB:
31.8		 4exsA-2yntB:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		6 / 9 VAL B  67
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.46A 4exsA-2yntB:
31.8		 4exsA-2yntB:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 TRP B  87
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 1.04A 4exsB-2yntB:
32.1		 4exsB-2yntB:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		6 / 8 VAL B  67
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.47A 4exsB-2yntB:
32.1		 4exsB-2yntB:
29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 LEU B  72
VAL B 259
LEU B 217
LEU B  54
LEU B 205
 None
 1.16A 4or0B-2yntB:
undetectable		 4or0B-2yntB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 PHE B 218
ARG B 121
ASP B  84
ILE B  83
 None
ZN  B1298 ( 4.5A)
None
None
 1.35A 5a06B-2yntB:
undetectable		 5a06B-2yntB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 TRP B  87
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 1.09A 5a5zA-2yntB:
32.1		 5a5zA-2yntB:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		6 / 8 VAL B  67
HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.59A 5a5zA-2yntB:
32.1		 5a5zA-2yntB:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 HIS B 196
CYH B 221
GLY B 232
HIS B 263
 ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
None
ZN  B1298 (-3.2A)
 0.35A 5a5zC-2yntB:
32.1		 5a5zC-2yntB:
29.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 HIS B 116
HIS B 118
ASP B 120
HIS B 196
HIS B 263
 ZN  B1297 (-3.2A)
ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-3.2A)
 0.75A 5ayaA-2yntB:
17.4		 5ayaA-2yntB:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE B 249
PHE B 218
ILE B 201
ILE B 216
THR B 115
 None
 1.07A 5e72A-2yntB:
undetectable		 5e72A-2yntB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ILE B 187
PHE B 218
PHE B 172
THR B 142
 None
 0.99A 5g08A-2yntB:
undetectable		 5g08A-2yntB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 GLY B 195
ILE B 249
VAL B 202
GLY B 220
ILE B 246
 None
 0.86A 5t8hB-2yntB:
undetectable		 5t8hB-2yntB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 HIS B 118
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 ZN  B1297 (-3.1A)
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 0.28A 5zj8A-2yntB:
15.8		 5zj8A-2yntB:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		5 / 8 TRP B  87
ASP B 120
HIS B 196
CYH B 221
HIS B 263
 None
ZN  B1298 (-2.4A)
ZN  B1297 (-3.2A)
ZN  B1298 (-2.2A)
ZN  B1298 (-3.2A)
 1.00A 5zj8A-2yntB:
15.8		 5zj8A-2yntB:
29.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ILE B 216
ASN B  70
CYH B 221
 None
None
ZN  B1298 (-2.2A)
 0.88A 6bp4A-2yntB:
undetectable		 6bp4A-2yntB:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2ynt GIM-1 PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 THR B 136
ARG B 121
HIS B 196
ASP B  84
 None
ZN  B1298 ( 4.5A)
ZN  B1297 (-3.2A)
None
 1.25A 6mn4E-2yntB:
undetectable		 6mn4E-2yntB:
25.26