SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ynx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ynx LACA THIOREDOXIN
(synthetic
construct) 		3 / 3 PHE A  10
GLN A   4
PHE A  79
 None
 0.81A 3rv5A-2ynxA:
undetectable		 3rv5A-2ynxA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2ynx LACA THIOREDOXIN
(synthetic
construct) 		3 / 3 TYR A  47
LYS A 102
LYS A  98
 None
 0.89A 5dbyA-2ynxA:
undetectable		 5dbyA-2ynxA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 2ynx LACA THIOREDOXIN
(synthetic
construct) 		4 / 5 PHE A  78
THR A  75
GLN A  87
ARG A 100
 None
 1.49A 5m35A-2ynxA:
undetectable		 5m35A-2ynxA:
23.76