SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		4 / 5 LYS A   6
LEU A  89
GLU A 203
LEU A  88
 None
 1.08A 1eta2-2yofA:
undetectable		 1eta2-2yofA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		3 / 3 ARG A  99
ASN A 113
THR A 158
 74W  A 211 (-4.0A)
None
None
 0.67A 2q63A-2yofA:
undetectable		 2q63A-2yofA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		4 / 6 LYS A   6
LEU A  89
GLU A 203
LEU A  88
 None
 1.08A 2roxB-2yofA:
undetectable		 2roxB-2yofA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		5 / 12 LEU A  59
GLU A 151
ARG A  47
SER A 103
TYR A 107
 74W  A 211 (-4.6A)
74W  A 211 (-3.2A)
74W  A 211 (-4.6A)
74W  A 211 ( 4.4A)
74W  A 211 (-3.5A)
 1.41A 3apvB-2yofA:
undetectable		 3apvB-2yofA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		3 / 3 PHE A  44
CYH A  97
PHE A  10
 ACT  A1211 (-4.2A)
None
None
 0.71A 3cr5X-2yofA:
undetectable		 3cr5X-2yofA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		5 / 12 ILE A 191
ASP A 130
PHE A 205
ILE A 127
ILE A  85
 None
 1.09A 3pwwA-2yofA:
undetectable		 3pwwA-2yofA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		3 / 3 ASP A  17
SER A 103
TYR A 107
 74W  A 211 (-2.6A)
74W  A 211 ( 4.4A)
74W  A 211 (-3.5A)
 0.83A 5glmA-2yofA:
undetectable		 5glmA-2yofA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2yof THYMIDYLATE KINASE
(Plasmodium
falciparum) 		5 / 12 TRP A  94
LEU A  32
VAL A  96
PHE A 133
VAL A 131
 None
 1.49A 6drxA-2yofA:
undetectable		 6drxA-2yofA:
15.85