SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		12 / 12 ALA A 156
TYR A 158
TYR A 184
ASP A 186
SER A 187
GLN A 188
GLU A 225
ASP A 227
GLU A 230
THR A 259
ARG A 264
ASP A 382
 None
None
None
None
None
None
None
None
None
PEG  A1445 (-3.5A)
PEG  A1445 (-3.3A)
None
 0.48A 1dy4A-2yokA:
69.7		 1dy4A-2yokA:
82.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 6 THR A  22
GLY A  91
LYS A 179
TYR A 180
 None
 1.34A 1gtiC-2yokA:
undetectable		 1gtiC-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 7 THR A  22
LEU A  89
GLY A  91
LYS A 179
TYR A 180
 None
PCA  A  18 ( 4.5A)
None
None
None
 1.44A 1gtiD-2yokA:
undetectable		 1gtiD-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 5 THR A  22
LEU A  89
GLY A  91
LYS A 179
TYR A 180
 None
PCA  A  18 ( 4.5A)
None
None
None
 1.46A 1gtiF-2yokA:
undetectable		 1gtiF-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 8 TYR A 171
PHE A 195
ASN A 174
GLY A 167
 None
PCA  A  18 ( 3.7A)
PCA  A  18 ( 3.6A)
None
 1.09A 1ykiC-2yokA:
undetectable
1ykiD-2yokA:
undetectable		 1ykiC-2yokA:
18.25
1ykiD-2yokA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 6 TYR A 180
ASP A  90
THR A  27
GLU A  26
 None
 1.44A 2dttB-2yokA:
undetectable
2dttC-2yokA:
undetectable		 2dttB-2yokA:
12.41
2dttC-2yokA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 8 LYS A 323
GLN A 325
PHE A 286
LEU A 295
 None
 0.96A 2eilP-2yokA:
undetectable
2eilW-2yokA:
undetectable		 2eilP-2yokA:
19.73
2eilW-2yokA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		3 / 3 GLY A 181
ARG A  55
TYR A 122
 None
 0.82A 2opxA-2yokA:
undetectable		 2opxA-2yokA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 8 LYS A 323
GLN A 325
PHE A 286
LEU A 295
 None
 0.93A 3asoC-2yokA:
undetectable
3asoJ-2yokA:
undetectable		 3asoC-2yokA:
19.73
3asoJ-2yokA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		3 / 3 TYR A 171
GLY A 167
ASP A 165
 None
 0.59A 3ou6C-2yokA:
undetectable		 3ou6C-2yokA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		3 / 3 SER A 333
GLY A 332
GLN A 330
 None
 0.53A 3v4tH-2yokA:
undetectable		 3v4tH-2yokA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 4 LEU A 149
GLY A 155
MET A 387
PHE A 111
 None
 1.44A 3vaqB-2yokA:
undetectable		 3vaqB-2yokA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 11 GLY A 183
ALA A 178
GLY A 166
MET A 162
VAL A 374
 None
 1.35A 4c5lA-2yokA:
undetectable		 4c5lA-2yokA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 10 GLY A 183
ALA A 178
GLY A 166
MET A 162
VAL A 374
 None
 1.33A 4c5lD-2yokA:
undetectable		 4c5lD-2yokA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 8 ASN A 174
LYS A  61
ASN A  86
THR A  60
 PCA  A  18 ( 3.6A)
None
None
None
 1.41A 4d1yA-2yokA:
undetectable
4d1yB-2yokA:
undetectable		 4d1yA-2yokA:
18.38
4d1yB-2yokA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		8 / 9 ASN A 154
ALA A 156
TYR A 158
TYR A 184
ASP A 186
GLU A 225
ASP A 227
TRP A 380
 None
 0.27A 4ipmA-2yokA:
61.9		 4ipmA-2yokA:
54.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		8 / 9 ASN A 154
TYR A 158
TYR A 184
ASP A 186
GLU A 225
ASP A 227
GLU A 230
TRP A 380
 None
 0.64A 4ipmA-2yokA:
61.9		 4ipmA-2yokA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		3 / 3 SER A 355
ASP A 272
GLN A 188
 None
PEG  A1445 (-3.9A)
None
 0.84A 4oltA-2yokA:
undetectable
4oltB-2yokA:
undetectable		 4oltA-2yokA:
19.04
4oltB-2yokA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 5 TYR A 184
SER A 378
ASP A 227
ASP A 275
 None
 1.05A 4qtuB-2yokA:
undetectable		 4qtuB-2yokA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		3 / 3 GLN A 188
SER A 355
ASP A 272
 None
None
PEG  A1445 (-3.9A)
 0.82A 4qwpA-2yokA:
undetectable
4qwpB-2yokA:
undetectable		 4qwpA-2yokA:
18.85
4qwpB-2yokA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 12 ILE A 434
VAL A 303
VAL A 304
LEU A 375
THR A 442
 None
 1.20A 5bykA-2yokA:
undetectable		 5bykA-2yokA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 12 GLY A 166
LEU A 121
TYR A 431
GLY A 118
THR A 182
 None
None
None
None
PCA  A  18 ( 4.9A)
 1.09A 5eskA-2yokA:
undetectable		 5eskA-2yokA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 5 GLY A 437
PRO A  43
GLN A  34
THR A 442
 None
 1.27A 5h5fA-2yokA:
undetectable		 5h5fA-2yokA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 11 GLN A 199
ASP A 163
TYR A 184
PRO A 190
LEU A 193
 None
 1.22A 5jh7B-2yokA:
undetectable		 5jh7B-2yokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 11 GLN A 199
ASP A 163
TYR A 184
PRO A 190
LEU A 193
 None
 1.21A 5jh7D-2yokA:
undetectable		 5jh7D-2yokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 8 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.02A 5vlmB-2yokA:
undetectable		 5vlmB-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		4 / 7 GLY A 258
GLN A 348
ASP A 270
ASP A 186
 None
 1.13A 5vlmE-2yokA:
undetectable		 5vlmE-2yokA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 12 GLY A 408
PRO A 289
GLY A 288
ASP A 391
LEU A 388
 None
 1.32A 5yniA-2yokA:
undetectable		 5yniA-2yokA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 2yok EXOGLUCANASE 1
(Trichoderma
harzianum) 		5 / 12 GLY A 408
PRO A 289
GLY A 288
ASP A 391
LEU A 388
 None
 1.34A 5ynmA-2yokA:
undetectable		 5ynmA-2yokA:
20.67