SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EKW_B_DR7B100_1 (PROTEASE)	2yop	PROTEIN FAM3B (Mus musculus)	5 / 10	ALA A 170 ASP A 169 ILE A 179 GLY A 175 ILE A 142	None	1.00A	3ekwA-2yopA: undetectable	3ekwA-2yopA: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NDW_A_RITA100_2 (PROTEASE)	2yop	PROTEIN FAM3B (Mus musculus)	5 / 9	ALA A 170 ASP A 169 ILE A 179 GLY A 175 ILE A 142	None	1.00A	3ndwB-2yopA: undetectable	3ndwB-2yopA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXX_C_DR7C100_2 (HIV-1 PROTEASE)	2yop	PROTEIN FAM3B (Mus musculus)	5 / 11	ALA A 170 ASP A 169 ILE A 179 GLY A 175 ILE A 142	None	1.01A	3oxxD-2yopA: undetectable	3oxxD-2yopA: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA902_1 (MRNA CAPPING ENZYME P5)	2yop	PROTEIN FAM3B (Mus musculus)	3 / 3	TYR A 87 ASP A 157 ASP A 85	None GOL A1192 (-3.0A) None	0.74A	5x6yA-2yopA: undetectable	5x6yA-2yopA: 15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B5V_B_ECLB1001_1 (TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5)	2yop	PROTEIN FAM3B (Mus musculus)	4 / 7	ALA A 112 ILE A 226 LEU A 78 ILE A 179	None	0.84A	6b5vA-2yopA: undetectable 6b5vB-2yopA: undetectable	6b5vA-2yopA: 15.34 6b5vB-2yopA: 15.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EKW_B_DR7B100_1","PROTEASE;PROTEASE","2yop","PROTEIN FAM3B","Mus musculus",5,"ALA A 170;ASP A 169;ILE A 179;GLY A 175;ILE A 142","None","1.00A","3ekwA-2yopA:undetectable","3ekwA-2yopA:19.69"],["3NDW_A_RITA100_2","PROTEASE;PROTEASE","2yop","PROTEIN FAM3B","Mus musculus",5,"ALA A 170;ASP A 169;ILE A 179;GLY A 175;ILE A 142","None","1.00A","3ndwB-2yopA:undetectable","3ndwB-2yopA:21.18"],["3OXX_C_DR7C100_2","HIV-1 PROTEASE;HIV-1 PROTEASE","2yop","PROTEIN FAM3B","Mus musculus",5,"ALA A 170;ASP A 169;ILE A 179;GLY A 175;ILE A 142","None","1.01A","3oxxD-2yopA:undetectable","3oxxD-2yopA:20.35"],["5X6Y_A_SAMA902_1","MRNA CAPPING ENZYME P5","2yop","PROTEIN FAM3B","Mus musculus",3,"TYR A  87;ASP A 157;ASP A  85","None;GOL A1192 (-3.0A);None","0.74A","5x6yA-2yopA:undetectable","5x6yA-2yopA:15.96"],["6B5V_B_ECLB1001_1","TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5;TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5","2yop","PROTEIN FAM3B","Mus musculus",4,"ALA A 112;ILE A 226;LEU A  78;ILE A 179","None","0.84A","6b5vA-2yopA:undetectable;6b5vB-2yopA:undetectable","6b5vA-2yopA:15.34;6b5vB-2yopA:15.34"]]