SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yoy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 5 PHE A 196
GLY A  69
SER A 193
THR A 192
 CU1  A 300 (-4.8A)
None
None
EDO  A1206 ( 3.0A)
 1.31A 1icvA-2yoyA:
undetectable
1icvB-2yoyA:
undetectable		 1icvA-2yoyA:
22.62
1icvB-2yoyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		5 / 8 GLY A  89
GLY A  58
LEU A  97
SER A  59
GLY A  96
 None
 1.44A 1jhqA-2yoyA:
undetectable		 1jhqA-2yoyA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 5 GLY A 185
ILE A  31
VAL A  67
SER A  36
 None
 1.16A 1rs7A-2yoyA:
undetectable		 1rs7A-2yoyA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A  37
VAL A 186
GLY A  77
 None
 0.64A 2avvE-2yoyA:
undetectable		 2avvE-2yoyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		3 / 3 THR A 135
PRO A 141
TYR A 180
 None
 0.92A 2dxrA-2yoyA:
undetectable		 2dxrA-2yoyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 8 ILE A  31
ILE A 183
TYR A 132
HIS A 169
 None
 1.04A 2zm8A-2yoyA:
undetectable		 2zm8A-2yoyA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 8 ILE A  31
ILE A 183
TYR A 132
HIS A 169
 None
 1.04A 2zmaA-2yoyA:
undetectable		 2zmaA-2yoyA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		3 / 3 ILE A 182
VAL A 199
ARG A  37
 None
 0.72A 3p73A-2yoyA:
1.9		 3p73A-2yoyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A  89
GLY A  58
GLY A  96
LYS A  56
ILE A  61
 None
 0.98A 5ehiA-2yoyA:
undetectable		 5ehiA-2yoyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A  89
GLY A  58
GLY A  96
LYS A  56
ILE A  61
 None
 0.93A 5eiwA-2yoyA:
undetectable		 5eiwA-2yoyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A  89
GLY A  58
GLY A  96
LYS A  56
ILE A  61
 None
 1.00A 5ekxA-2yoyA:
undetectable		 5ekxA-2yoyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		5 / 12 GLY A  89
GLY A  58
GLY A  96
LYS A  56
ILE A  61
 None
 0.98A 5njvD-2yoyA:
undetectable		 5njvD-2yoyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		3 / 3 ARG A 147
PRO A  78
TYR A 133
 None
 0.99A 5tzoB-2yoyA:
undetectable		 5tzoB-2yoyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 2yoy RBAM17540
(Bacillus
amyloliquefacien
s) 		4 / 6 ASN A 198
TYR A  30
VAL A  67
VAL A  60
 None
 1.09A 6f32B-2yoyA:
undetectable		 6f32B-2yoyA:
16.63