SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 11 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.42A 1cmaA-2yp2A:
undetectable
1cmaB-2yp2A:
undetectable
1cmaA-2yp2A:
11.20
1cmaB-2yp2A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 10 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.33A 1cmcA-2yp2A:
undetectable
1cmcB-2yp2A:
undetectable
1cmcA-2yp2A:
11.20
1cmcB-2yp2A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 10 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.34A 1cmcA-2yp2A:
undetectable
1cmcB-2yp2A:
undetectable
1cmcA-2yp2A:
11.20
1cmcB-2yp2A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 194
THR A 155
LEU A 251
GLY A 249
None
0.91A 1gtiB-2yp2A:
undetectable
1gtiB-2yp2A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 12 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.46A 1mj2A-2yp2A:
undetectable
1mj2B-2yp2A:
undetectable
1mj2A-2yp2A:
11.02
1mj2B-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.24A 1mj2C-2yp2A:
undetectable
1mj2D-2yp2A:
undetectable
1mj2C-2yp2A:
11.02
1mj2D-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 9 GLU A  89
ARG A 269
GLU A 396
PHE A  87
GLY A 116
None
1.20A 1mjlA-2yp2A:
undetectable
1mjlB-2yp2A:
undetectable
1mjlA-2yp2A:
11.02
1mjlB-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 12 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.42A 1mjoC-2yp2A:
undetectable
1mjoD-2yp2A:
undetectable
1mjoC-2yp2A:
11.02
1mjoD-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 11 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.36A 1mjqA-2yp2A:
undetectable
1mjqB-2yp2A:
undetectable
1mjqA-2yp2A:
11.02
1mjqB-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 11 PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.18A 1mjqA-2yp2A:
undetectable
1mjqB-2yp2A:
undetectable
1mjqA-2yp2A:
11.02
1mjqB-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 10 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.39A 1mjqC-2yp2A:
undetectable
1mjqD-2yp2A:
undetectable
1mjqC-2yp2A:
11.02
1mjqD-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 12 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.43A 1mjqC-2yp2A:
undetectable
1mjqD-2yp2A:
undetectable
1mjqC-2yp2A:
11.02
1mjqD-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 10 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.36A 1mjqG-2yp2A:
undetectable
1mjqH-2yp2A:
undetectable
1mjqG-2yp2A:
11.02
1mjqH-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 10 PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.17A 1mjqG-2yp2A:
undetectable
1mjqH-2yp2A:
undetectable
1mjqG-2yp2A:
11.02
1mjqH-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 11 GLU A  89
ARG A 269
GLU A 396
ALA A 113
PHE A  87
GLY A 116
None
1.40A 1mjqI-2yp2A:
undetectable
1mjqJ-2yp2A:
undetectable
1mjqI-2yp2A:
11.02
1mjqJ-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
6 / 12 ALA A 113
PHE A  87
GLY A 116
GLU A  89
ARG A 269
GLU A 396
None
1.43A 1mjqI-2yp2A:
undetectable
1mjqJ-2yp2A:
undetectable
1mjqI-2yp2A:
11.02
1mjqJ-2yp2A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 ILE A 245
PRO A 254
PHE A 125
ASN A 126
None
0.86A 1oniG-2yp2A:
undetectable
1oniI-2yp2A:
undetectable
1oniG-2yp2A:
14.32
1oniI-2yp2A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 THR A 451
ARG A 450
SER A 369
ARG A 482
LEU A 455
None
1.49A 2a5hD-2yp2A:
undetectable
2a5hD-2yp2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 5 PRO A 227
PRO A 185
ILE A 217
GLY A 218
None
1.17A 2jkjD-2yp2A:
undetectable
2jkjD-2yp2A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 GLY A 286
SER A  47
SER A 279
ASP A  53
ILE A 274
None
1.16A 3iv6D-2yp2A:
undetectable
3iv6D-2yp2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 8 THR A 440
LEU A 439
GLN A 376
ALA A 372
None
0.99A 3kp6A-2yp2A:
undetectable
3kp6A-2yp2A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 8 LEU A 177
LEU A  66
ARG A 150
ILE A 179
None
0.68A 3ln1A-2yp2A:
undetectable
3ln1A-2yp2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 177
LEU A  66
ARG A 150
ILE A 179
None
0.69A 3ln1B-2yp2A:
undetectable
3ln1B-2yp2A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
3 / 3 ARG A 383
LEU A 384
THR A 318
None
None
NAG  A 801 (-3.5A)
0.85A 3oxcA-2yp2A:
undetectable
3oxcA-2yp2A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.81A 4eq4A-2yp2A:
undetectable
4eq4A-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.82A 4eqlA-2yp2A:
undetectable
4eqlA-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.83A 4eqlB-2yp2A:
undetectable
4eqlB-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 PHE A 392
TYR A 302
HIS A  56
ILE A  58
None
0.98A 4g5jA-2yp2A:
undetectable
4g5jA-2yp2A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 6 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.82A 4l39A-2yp2A:
undetectable
4l39A-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 7 LEU A 194
TYR A 195
ILE A 252
GLY A 134
None
0.82A 4l39B-2yp2A:
undetectable
4l39B-2yp2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
3 / 3 LEU A 455
LYS A 452
THR A 451
None
0.54A 4lj0A-2yp2A:
undetectable
4lj0A-2yp2A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 4 HIS A  18
ALA A  19
VAL A  20
GLU A  35
None
1.22A 4n6pA-2yp2A:
0.0
4n6pA-2yp2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 LEU A 439
ALA A 373
THR A  40
ALA A 317
ILE A 437
None
None
NAG  A 802 ( 4.0A)
None
None
1.06A 4o2bB-2yp2A:
undetectable
4o2bB-2yp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 5 ILE A 217
PRO A 185
TYR A 233
VAL A 213
None
0.86A 4s0vA-2yp2A:
undetectable
4s0vA-2yp2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 8 ASN A 464
MET A 462
PHE A 338
TRP A 343
None
1.49A 4v2zB-2yp2A:
undetectable
4v2zB-2yp2A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 8 ASN A 464
MET A 462
PHE A 338
TRP A 343
None
1.42A 4v30B-2yp2A:
undetectable
4v30B-2yp2A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 5 ARG A 269
HIS A 393
ALA A 113
GLU A 396
None
1.27A 5a06C-2yp2A:
undetectable
5a06D-2yp2A:
undetectable
5a06C-2yp2A:
20.00
5a06D-2yp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 4 ARG A 269
HIS A 393
ALA A 113
GLU A 396
None
1.29A 5a06A-2yp2A:
0.0
5a06F-2yp2A:
0.2
5a06A-2yp2A:
20.00
5a06F-2yp2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
4 / 4 GLN A 434
THR A 436
GLU A 432
LEU A 314
None
1.44A 5m66A-2yp2A:
undetectable
5m66A-2yp2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 LEU A 439
ALA A 373
THR A  40
ALA A 317
ILE A 437
None
None
NAG  A 802 ( 4.0A)
None
None
1.07A 5mioB-2yp2A:
undetectable
5mioB-2yp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
5 / 12 LEU A 439
ALA A 373
THR A  40
ALA A 317
ILE A 437
None
None
NAG  A 802 ( 4.0A)
None
None
1.07A 5nm5B-2yp2A:
undetectable
5nm5B-2yp2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2yp2 HEMAGGLUTININ
(Influenza
A
virus)
3 / 3 ARG A 261
PHE A 120
PHE A 174
None
0.85A 6nknC-2yp2A:
undetectable
6nknJ-2yp2A:
undetectable
6nknC-2yp2A:
17.74
6nknJ-2yp2A:
7.75