SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2yp6 THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A 149
PRO A  50
ALA A  49
ILE A 164
 None
 0.78A 1n49A-2yp6A:
undetectable		 1n49A-2yp6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2yp6 THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 181
ALA A 177
LEU A  91
LEU A  94
ILE A 172
 None
 1.00A 3lbdA-2yp6A:
undetectable		 3lbdA-2yp6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2yp6 THIOREDOXIN FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ASP A  51
LEU A  64
SER A  65
GLY A 162
ASP A  48
 None
 1.19A 3sfuC-2yp6A:
undetectable		 3sfuC-2yp6A:
15.37