SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ypb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_RALB600_1 (ESTROGEN RECEPTOR)	2ypb	T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 TRANSCRIPTION FACTOR E2-ALPHA (Homo sapiens)	5 / 12	ALA A 206 GLU A 209 LEU A 210 LEU B 569 LEU A 229	None	1.04A	1errB-2ypbA: undetectable	1errB-2ypbA: 19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_RALB600_1 (ESTROGEN RECEPTOR)	2ypb	T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 TRANSCRIPTION FACTOR E2-ALPHA (Homo sapiens)	5 / 12	ALA B 565 GLU B 568 LEU B 569 LEU A 210 LEU B 589	None	0.97A	1errB-2ypbB: undetectable	1errB-2ypbB: 16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_E_NCAE507_0 (NAD-DEPENDENT DEACETYLASE 2)	2ypb	T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 TRANSCRIPTION FACTOR E2-ALPHA (Homo sapiens; Homo sapiens)	4 / 7	ILE B 588 PHE A 207 LEU A 210 ILE B 562	None	0.93A	1yc2E-2ypbB: undetectable	1yc2E-2ypbB: 14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O7G_A_ASCA303_0 (PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2)	2ypb	T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 TRANSCRIPTION FACTOR E2-ALPHA (Homo sapiens; Homo sapiens)	4 / 7	PHE B 566 ILE B 562 ASN A 204 ARG B 558	None	1.11A	4o7gA-2ypbB: undetectable 4o7gB-2ypbB: undetectable	4o7gA-2ypbB: 15.93 4o7gB-2ypbB: 15.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_B_RALB600_1","ESTROGEN RECEPTOR","2ypb","T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1;TRANSCRIPTION FACTOR E2-ALPHA","Homo sapiens",5,"ALA A 206;GLU A 209;LEU A 210;LEU B 569;LEU A 229","None","1.04A","1errB-2ypbA:undetectable","1errB-2ypbA:19.21"],["1ERR_B_RALB600_1","ESTROGEN RECEPTOR","2ypb","T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1;TRANSCRIPTION FACTOR E2-ALPHA","Homo sapiens",5,"ALA B 565;GLU B 568;LEU B 569;LEU A 210;LEU B 589","None","0.97A","1errB-2ypbB:undetectable","1errB-2ypbB:16.60"],["1YC2_E_NCAE507_0","NAD-DEPENDENT DEACETYLASE 2","2ypb","T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1;TRANSCRIPTION FACTOR E2-ALPHA","Homo sapiens;Homo sapiens",4,"ILE B 588;PHE A 207;LEU A 210;ILE B 562","None","0.93A","1yc2E-2ypbB:undetectable","1yc2E-2ypbB:14.62"],["4O7G_A_ASCA303_0","PROBABLE TRANSMEMBRANE ASCORBATE FERRIREDUCTASE 2","2ypb","T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1;TRANSCRIPTION FACTOR E2-ALPHA","Homo sapiens;Homo sapiens",4,"PHE B 566;ILE B 562;ASN A 204;ARG B 558","None","1.11A","4o7gA-2ypbB:undetectable;4o7gB-2ypbB:undetectable","4o7gA-2ypbB:15.93;4o7gB-2ypbB:15.93"]]