SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ypj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.38A 1mj2B-2ypjA:
undetectable		 1mj2B-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.32A 1mj2D-2ypjA:
undetectable		 1mj2D-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.38A 1mjoB-2ypjA:
undetectable		 1mjoB-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.40A 1mjoA-2ypjA:
undetectable		 1mjoA-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
 None
 1.36A 1mjoD-2ypjA:
undetectable		 1mjoD-2ypjA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		5 / 12 TYR A 706
MET A 620
LEU A 624
SER A 592
ILE A 686
 None
 1.31A 1xotA-2ypjA:
undetectable		 1xotA-2ypjA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 7 PHE A 628
LEU A 641
PHE A 643
ILE A 613
 None
 0.91A 2v0mC-2ypjA:
undetectable		 2v0mC-2ypjA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 8 ILE A 705
GLY A 704
LEU A 622
LEU A 624
 None
 0.86A 2vctC-2ypjA:
undetectable		 2vctC-2ypjA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		5 / 12 SER A 594
ASN A 635
VAL A 697
GLY A 696
ALA A 597
 None
 1.28A 2x2iC-2ypjA:
undetectable		 2x2iC-2ypjA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		5 / 8 PHE A 666
VAL A 699
ASP A 633
TYR A 634
ALA A 610
 None
 1.29A 4m48A-2ypjA:
undetectable		 4m48A-2ypjA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 5 PHE A 643
LEU A 590
GLY A 704
ILE A 671
 None
 0.87A 5ik1A-2ypjA:
undetectable		 5ik1A-2ypjA:
16.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 2ypj ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens) 		4 / 7 LEU A 683
TRP A 646
GLU A 612
SER A 609
 None
BGC  A1712 (-3.9A)
XYS  A1715 ( 4.9A)
None
 1.27A 5umwA-2ypjA:
undetectable
5umwF-2ypjA:
undetectable		 5umwA-2ypjA:
30.46
5umwF-2ypjA:
30.46