SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ypq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		6 / 12 PHE A  91
GLY A 149
LEU A 250
PRO A  38
VAL A 251
ALA A 172
 None
 1.48A 1gseA-2ypqA:
undetectable		 1gseA-2ypqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 6 MET A 109
VAL A 112
LEU A 113
PHE A  80
 None
 1.05A 1x8vA-2ypqA:
undetectable		 1x8vA-2ypqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 241
LEU A 107
ALA A 110
LEU A 196
VAL A 197
 TRP  A1464 ( 3.9A)
TRP  A1464 ( 4.4A)
TRP  A1464 (-3.6A)
None
None
 1.04A 2bxeB-2ypqA:
undetectable		 2bxeB-2ypqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 241
LEU A 107
ALA A 110
LEU A 196
VAL A 197
 TRP  A1464 ( 3.9A)
TRP  A1464 ( 4.4A)
TRP  A1464 (-3.6A)
None
None
 1.04A 2bxgB-2ypqA:
undetectable		 2bxgB-2ypqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 11 SER A 136
VAL A 251
ARG A 135
SER A 146
ILE A 152
 None
None
None
SO4  A1467 ( 4.5A)
None
 1.17A 2zbzA-2ypqA:
undetectable		 2zbzA-2ypqA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 124
ALA A 125
ALA A 110
GLU A 242
THR A 278
 None
None
TRP  A1464 (-3.6A)
GOL  A1469 (-4.7A)
None
 1.30A 3dl9B-2ypqA:
undetectable		 3dl9B-2ypqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 THR A  59
VAL A  60
VAL A 103
LEU A 186
ILE A 243
 None
 1.33A 3elzA-2ypqA:
undetectable		 3elzA-2ypqA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 252
ASP A 273
THR A 285
ILE A 293
LEU A 323
 None
 0.98A 3hj3D-2ypqA:
undetectable		 3hj3D-2ypqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 GLU A 411
GLY A 339
GLU A 283
GLY A 282
ASN A 310
 MN  A1463 (-2.3A)
None
None
PO4  A1466 (-3.3A)
None
 1.32A 3jzjA-2ypqA:
undetectable		 3jzjA-2ypqA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  84
ALA A 125
ILE A  99
THR A 187
ILE A 243
 None
None
None
GOL  A1469 (-3.9A)
None
 1.00A 3tkgC-2ypqA:
undetectable		 3tkgC-2ypqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 394
PHE A 395
GLY A 407
THR A 403
 None
 1.11A 3vnsA-2ypqA:
undetectable		 3vnsA-2ypqA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 302
LEU A  71
VAL A 122
ALA A 245
SER A 246
 None
 1.26A 4a84A-2ypqA:
undetectable		 4a84A-2ypqA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 104
THR A 413
GLU A 415
THR A 446
 None
 1.25A 4eahA-2ypqA:
0.0
4eahE-2ypqA:
0.0
4eahG-2ypqA:
0.4		 4eahA-2ypqA:
23.09
4eahE-2ypqA:
23.09
4eahG-2ypqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 SER A 275
TYR A 254
GLN A 130
ALA A 132
GLY A 282
 None
None
None
None
PO4  A1466 (-3.3A)
 1.00A 4j7xB-2ypqA:
undetectable		 4j7xB-2ypqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 286
TYR A 319
GLY A 308
LEU A 347
VAL A 343
 None
 1.31A 4mjrA-2ypqA:
undetectable		 4mjrA-2ypqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 447
LEU A 450
SER A 449
ASP A  93
 None
 1.13A 4qtuD-2ypqA:
undetectable		 4qtuD-2ypqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.09A 4w5oA-2ypqA:
undetectable		 4w5oA-2ypqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.07A 4z4cA-2ypqA:
undetectable		 4z4cA-2ypqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.12A 4z4dA-2ypqA:
undetectable		 4z4dA-2ypqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.11A 4z4eA-2ypqA:
undetectable		 4z4eA-2ypqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 259
LEU A  26
LEU A  30
ALA A 291
LEU A 252
 None
 1.17A 4z90A-2ypqA:
0.2
4z90B-2ypqA:
0.4
4z90C-2ypqA:
0.2
4z90D-2ypqA:
undetectable
4z90E-2ypqA:
undetectable		 4z90A-2ypqA:
21.75
4z90B-2ypqA:
21.75
4z90C-2ypqA:
21.75
4z90D-2ypqA:
21.75
4z90E-2ypqA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 186
LEU A 107
ALA A 192
ALA A 125
ILE A 127
 None
TRP  A1464 ( 4.4A)
TRP  A1464 (-4.6A)
None
None
 1.30A 5nm5B-2ypqA:
undetectable		 5nm5B-2ypqA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		4 / 6 PHE A  80
PRO A 120
VAL A 121
ALA A 117
 None
 1.05A 5t7bA-2ypqA:
undetectable		 5t7bA-2ypqA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG
(Mycobacterium
tuberculosis) 		5 / 12 GLN A  70
LEU A  67
GLN A  68
ASP A 324
ILE A 362
 None
 1.39A 5uh6C-2ypqA:
undetectable		 5uh6C-2ypqA:
18.39