SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		5 / 11 PHE A 144
LEU A  92
GLY A 121
ILE A  51
VAL A  33
 None
 1.17A 1phgA-2ypsA:
undetectable		 1phgA-2ypsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.18A 2zawA-2ypsA:
undetectable		 2zawA-2ypsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.08A 3fwgA-2ypsA:
undetectable		 3fwgA-2ypsA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 7 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.09A 3fwgB-2ypsA:
undetectable		 3fwgB-2ypsA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.09A 3wrjE-2ypsA:
undetectable		 3wrjE-2ypsA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.06A 4ek1A-2ypsA:
undetectable		 4ek1A-2ypsA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.12A 4kkyX-2ypsA:
undetectable		 4kkyX-2ypsA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 6 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.04A 4l4cA-2ypsA:
undetectable		 4l4cA-2ypsA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 7 VAL A  67
PHE A 144
ILE A 126
ASN A  56
 None
 0.98A 5hieC-2ypsA:
undetectable		 5hieC-2ypsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2yps SORTING NEXIN-3
(Homo
sapiens) 		4 / 7 PHE A 144
LEU A 122
VAL A  33
ASP A  73
 None
 1.05A 5wk9A-2ypsA:
undetectable		 5wk9A-2ypsA:
17.53