SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ILE A  74
LEU A  94
ALA A  43
VAL A  49
 None
 0.72A 1a29A-2yq4A:
undetectable		 1a29A-2yq4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 4 ILE A 203
MET A 226
VAL A 241
GLY A 152
 None
 1.28A 1e06B-2yq4A:
undetectable		 1e06B-2yq4A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 SER A  37
VAL A  61
ASN A  85
ASP A  58
 None
 1.01A 1hwiB-2yq4A:
undetectable		 1hwiB-2yq4A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 SER A  37
VAL A  61
ASN A  85
ASP A  58
 None
 1.02A 1hwkA-2yq4A:
undetectable		 1hwkA-2yq4A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 SER A  37
VAL A  61
ASN A  85
ASP A  58
 None
 1.01A 1hwkC-2yq4A:
undetectable		 1hwkC-2yq4A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 SER A  37
VAL A  61
ASN A  85
ASP A  58
 None
 1.02A 1hwkD-2yq4A:
undetectable		 1hwkD-2yq4A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 LEU A 223
ASP A 242
THR A 243
HIS A 298
 None
 1.21A 1v55C-2yq4A:
undetectable
1v55N-2yq4A:
undetectable
1v55P-2yq4A:
undetectable		 1v55C-2yq4A:
21.28
1v55N-2yq4A:
20.92
1v55P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 11 GLY A 265
GLU A 239
LEU A 287
GLY A 238
GLU A 266
 None
 1.20A 2fn1A-2yq4A:
undetectable		 2fn1A-2yq4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		3 / 3 ASN A 148
ILE A 203
MET A 116
 None
 0.80A 2h42C-2yq4A:
undetectable		 2h42C-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ILE A 159
LEU A 153
GLY A 155
TYR A 191
 None
 0.93A 2tsrB-2yq4A:
undetectable		 2tsrB-2yq4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 5 VAL A  62
VAL A  61
THR A  89
THR A  36
 None
 1.25A 3bjwG-2yq4A:
undetectable		 3bjwG-2yq4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 5 VAL A  62
VAL A  61
THR A  89
THR A  36
 None
 1.24A 3bjwD-2yq4A:
1.5		 3bjwD-2yq4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 ASN A 292
VAL A 241
ILE A 255
LEU A 223
THR A 262
 None
 1.13A 3fl9B-2yq4A:
undetectable		 3fl9B-2yq4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 11 ASN A 292
VAL A 241
ILE A 255
LEU A 223
THR A 262
 None
 1.11A 3fl9C-2yq4A:
undetectable		 3fl9C-2yq4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 ILE A 154
GLY A 155
ASP A 178
ALA A 180
PHE A 194
 None
 0.85A 3jb1A-2yq4A:
undetectable		 3jb1A-2yq4A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.22A 3wg7A-2yq4A:
undetectable
3wg7C-2yq4A:
undetectable
3wg7P-2yq4A:
undetectable		 3wg7A-2yq4A:
20.92
3wg7C-2yq4A:
21.28
3wg7P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 ASN A 182
VAL A 156
GLY A 157
SER A 161
LEU A 189
 None
 1.36A 4ot2A-2yq4A:
undetectable		 4ot2A-2yq4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 9 SER A 229
ALA A 256
LEU A 119
ILE A 142
 None
 0.70A 4xtaA-2yq4A:
undetectable		 4xtaA-2yq4A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.21A 5b3sA-2yq4A:
undetectable
5b3sC-2yq4A:
undetectable
5b3sP-2yq4A:
undetectable		 5b3sA-2yq4A:
20.92
5b3sC-2yq4A:
21.28
5b3sP-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ILE A 203
GLY A 259
LEU A 246
LEU A 223
 None
 0.85A 5hs1A-2yq4A:
undetectable		 5hs1A-2yq4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 ILE A  84
VAL A  49
ALA A 322
VAL A  71
GLY A 325
 None
 1.09A 5igjA-2yq4A:
undetectable		 5igjA-2yq4A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 GLY A  80
ASP A 261
HIS A 298
TYR A 102
MET A 310
 None
 1.19A 5igvA-2yq4A:
undetectable		 5igvA-2yq4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 VAL A  49
LEU A  51
ALA A   5
LEU A  66
 None
 0.57A 5jq7A-2yq4A:
undetectable		 5jq7A-2yq4A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 10 LEU A 206
ILE A 154
GLY A 155
GLY A 160
VAL A 151
 None
 1.06A 5o96C-2yq4A:
4.0
5o96D-2yq4A:
4.5		 5o96C-2yq4A:
21.47
5o96D-2yq4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 LEU A 223
ASP A 242
THR A 243
HIS A 298
 None
 1.22A 5w97C-2yq4A:
undetectable
5w97a-2yq4A:
undetectable
5w97c-2yq4A:
undetectable		 5w97C-2yq4A:
21.28
5w97a-2yq4A:
20.92
5w97c-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.20A 5wauA-2yq4A:
undetectable
5wauC-2yq4A:
undetectable
5wauc-2yq4A:
undetectable		 5wauA-2yq4A:
20.92
5wauC-2yq4A:
21.28
5wauc-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.21A 5z84A-2yq4A:
undetectable
5z84C-2yq4A:
undetectable
5z84P-2yq4A:
undetectable		 5z84A-2yq4A:
20.92
5z84C-2yq4A:
21.28
5z84P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 LEU A 223
ASP A 242
THR A 243
HIS A 298
 None
 1.24A 5z84C-2yq4A:
undetectable
5z84N-2yq4A:
undetectable
5z84P-2yq4A:
undetectable		 5z84C-2yq4A:
21.28
5z84N-2yq4A:
20.92
5z84P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.22A 5z85A-2yq4A:
undetectable
5z85C-2yq4A:
undetectable
5z85P-2yq4A:
undetectable		 5z85A-2yq4A:
20.92
5z85C-2yq4A:
21.28
5z85P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 7 LEU A 223
ASP A 242
THR A 243
HIS A 298
 None
 1.24A 5z85C-2yq4A:
undetectable
5z85N-2yq4A:
undetectable
5z85P-2yq4A:
undetectable		 5z85C-2yq4A:
21.28
5z85N-2yq4A:
20.92
5z85P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.22A 5z86A-2yq4A:
undetectable
5z86C-2yq4A:
undetectable
5z86P-2yq4A:
undetectable		 5z86A-2yq4A:
20.92
5z86C-2yq4A:
21.28
5z86P-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		4 / 8 ASP A 242
THR A 243
HIS A 298
LEU A 223
 None
 1.22A 5zcqA-2yq4A:
undetectable
5zcqC-2yq4A:
undetectable
5zcqP-2yq4A:
undetectable		 5zcqA-2yq4A:
20.92
5zcqC-2yq4A:
21.28
5zcqP-2yq4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2yq4 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
(Lactobacillus
delbrueckii) 		5 / 12 GLN A 222
ALA A 258
LEU A 246
ALA A 245
LEU A 250
 None
 1.03A 6bq4A-2yq4A:
6.6		 6bq4A-2yq4A:
13.66