SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		5 / 12 ASP A 111
LEU A  86
LYS A  82
ILE A 160
LEU A 100
 None
 1.19A 1lhuA-2yqeA:
undetectable		 1lhuA-2yqeA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		6 / 9 ILE A 128
GLY A 123
SER A 116
LEU A 115
SER A 114
GLU A 121
 None
 1.18A 3ai9X-2yqeA:
undetectable		 3ai9X-2yqeA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		4 / 8 TYR A 164
ILE A 161
ILE A 160
ILE A 102
 None
 0.87A 3p4wC-2yqeA:
undetectable		 3p4wC-2yqeA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		5 / 9 ASP A 131
ILE A 128
GLY A 150
ILE A 149
ILE A 118
 None
 0.98A 3s43A-2yqeA:
undetectable		 3s43A-2yqeA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		4 / 7 TYR A 164
ILE A 161
ILE A 160
ILE A 102
 None
 0.87A 5murB-2yqeA:
undetectable		 5murB-2yqeA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D
(Homo
sapiens) 		5 / 12 ILE A 128
SER A 116
LEU A 115
SER A 114
VAL A 137
 None
 1.11A 5twjC-2yqeA:
undetectable		 5twjC-2yqeA:
20.61