SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 7 CYH A 306
PHE A 398
PRO A 399
SER A 400
 None
 1.33A 1gyxA-2yqhA:
0.8
1gyxB-2yqhA:
1.0		 1gyxA-2yqhA:
9.73
1gyxB-2yqhA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 10 ARG A 435
LEU A 130
ILE A 139
PHE A 137
GLY A 124
 None
 1.33A 2bxqA-2yqhA:
undetectable		 2bxqA-2yqhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 6 ALA A 264
TYR A 467
ILE A 144
ILE A  99
 None
 1.11A 2dcfA-2yqhA:
undetectable		 2dcfA-2yqhA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 7 ILE A   9
SER A  12
PHE A  22
PHE A  36
 None
 1.16A 2qb4A-2yqhA:
undetectable		 2qb4A-2yqhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 12 ILE A 296
THR A 281
VAL A 283
ILE A 336
GLU A 309
 None
None
None
None
GN1  A1001 (-3.0A)
 1.31A 2yzqA-2yqhA:
undetectable		 2yzqA-2yqhA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 7 ALA A 264
TYR A 467
ILE A 144
ILE A  99
 None
 1.10A 2zm7A-2yqhA:
undetectable		 2zm7A-2yqhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 8 PHE A 362
GLU A 309
ILE A 364
ALA A  56
 None
GN1  A1001 (-3.0A)
None
None
 0.76A 3aodA-2yqhA:
undetectable		 3aodA-2yqhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 LEU A 202
PRO A 203
LEU A 390
 None
 0.55A 3hcrA-2yqhA:
undetectable		 3hcrA-2yqhA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 10 ILE A 388
GLY A 387
SER A 371
LEU A 390
SER A 223
 None
 1.39A 3ik6B-2yqhA:
undetectable
3ik6E-2yqhA:
undetectable		 3ik6B-2yqhA:
17.78
3ik6E-2yqhA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 10 SER A 371
LEU A 390
SER A 223
ILE A 388
GLY A 387
 None
 1.37A 3iluB-2yqhA:
undetectable
3iluE-2yqhA:
undetectable		 3iluB-2yqhA:
17.78
3iluE-2yqhA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 LYS A 444
ILE A 267
PHE A 268
 None
 0.62A 3j7zS-2yqhA:
undetectable
3j7za-2yqhA:
undetectable		 3j7zS-2yqhA:
13.98
3j7za-2yqhA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		5 / 12 LEU A 117
GLY A 112
ASN A 198
GLY A 171
GLY A 124
 None
 1.01A 3ku1G-2yqhA:
undetectable		 3ku1G-2yqhA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 8 ILE A  99
GLY A 100
VAL A 106
GLN A 193
 None
 0.88A 4acbB-2yqhA:
2.1
4acbC-2yqhA:
2.1		 4acbB-2yqhA:
24.09
4acbC-2yqhA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 1.01A 4bupB-2yqhA:
undetectable		 4bupB-2yqhA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		4 / 5 LEU A 243
LEU A 234
MET A 253
TRP A 353
 None
 1.24A 4do3A-2yqhA:
undetectable		 4do3A-2yqhA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 SER A 342
TYR A 341
TYR A 340
 None
 0.78A 5lakA-2yqhA:
undetectable
5lakI-2yqhA:
undetectable		 5lakA-2yqhA:
19.80
5lakI-2yqhA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 SER A 342
TYR A 341
TYR A 340
 None
 0.72A 5lakC-2yqhA:
undetectable
5lakJ-2yqhA:
undetectable		 5lakC-2yqhA:
19.80
5lakJ-2yqhA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		6 / 12 GLY A 111
GLY A 228
GLY A 226
HIS A 363
GLU A 391
VAL A 397
 None
 1.22A 5njvC-2yqhA:
undetectable		 5njvC-2yqhA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		6 / 12 GLY A 200
HIS A 363
GLU A 391
VAL A 397
PHE A 398
ILE A 394
 None
 1.40A 5vimA-2yqhA:
undetectable		 5vimA-2yqhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		6 / 12 GLY A 228
GLY A 226
GLY A 200
GLU A 391
PHE A 398
ILE A 394
 None
 1.48A 5vimB-2yqhA:
undetectable		 5vimB-2yqhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 0.94A 5wbvA-2yqhA:
undetectable		 5wbvA-2yqhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 HIS A 363
GLU A 391
ASN A 227
 None
None
GN1  A1001 (-3.1A)
 0.94A 5wbvB-2yqhA:
undetectable		 5wbvB-2yqhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		6 / 12 GLY A 111
GLY A 228
GLY A 226
HIS A 363
GLU A 391
VAL A 397
 None
 1.22A 5wz2C-2yqhA:
undetectable		 5wz2C-2yqhA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 ILE A 364
ASN A 206
CYH A 221
 None
 0.83A 6bp4A-2yqhA:
undetectable		 6bp4A-2yqhA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Candida
albicans) 		3 / 3 VAL A 284
GLU A 410
ILE A 336
 None
SO4  A1102 ( 4.5A)
None
 0.46A 6f7lB-2yqhA:
1.0		 6f7lB-2yqhA:
21.22