SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yqu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 PRO A 167
VAL A 166
VAL A 193
ILE A  58
GLY A 190
 None
 1.42A 13gsA-2yquA:
undetectable		 13gsA-2yquA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 9 PRO A 167
VAL A 166
VAL A 193
ILE A  58
GLY A 190
 None
 1.42A 13gsB-2yquA:
undetectable		 13gsB-2yquA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 VAL A 407
GLY A 408
GLY A 404
PRO A 344
VAL A 177
 None
 1.06A 1fduA-2yquA:
5.9		 1fduA-2yquA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 VAL A 407
GLY A 408
GLY A 404
PRO A 344
VAL A 177
 None
 1.04A 1fduC-2yquA:
undetectable		 1fduC-2yquA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 0.86A 1gtiA-2yquA:
undetectable		 1gtiA-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 0.79A 1gtiB-2yquA:
undetectable		 1gtiB-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 1.01A 1gtiD-2yquA:
undetectable		 1gtiD-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 0.80A 1gtiE-2yquA:
undetectable		 1gtiE-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 ALA A 130
GLU A 129
LEU A 128
VAL A  30
 None
 0.88A 1hk2A-2yquA:
2.7		 1hk2A-2yquA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 11 ALA A 313
ILE A   7
THR A  39
LEU A 290
VAL A 286
 FAD  A1601 (-3.6A)
None
FAD  A1601 (-3.5A)
None
None
 1.14A 1rv7A-2yquA:
undetectable
1rv7B-2yquA:
undetectable		 1rv7A-2yquA:
13.57
1rv7B-2yquA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		3 / 3 GLU A 345
THR A 342
LEU A 203
 None
 0.54A 1v8bC-2yquA:
3.5		 1v8bC-2yquA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 11 GLY A 275
ALA A 274
ILE A 133
ALA A 299
ILE A 297
 None
 1.03A 2b60B-2yquA:
undetectable		 2b60B-2yquA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 GLN A 221
LEU A 223
VAL A 184
VAL A 340
 None
 0.99A 2bdmA-2yquA:
undetectable		 2bdmA-2yquA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 9 LEU A 411
LEU A 441
HIS A 432
ALA A 424
ALA A 417
 None
 1.43A 2bxcB-2yquA:
undetectable		 2bxcB-2yquA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 MET A 206
LEU A 203
VAL A 407
GLY A 404
 None
 1.10A 2qd5B-2yquA:
2.8		 2qd5B-2yquA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 GLY A  10
GLY A  37
ILE A 318
GLY A  13
GLY A  12
 FAD  A1601 (-3.5A)
None
None
None
FAD  A1601 (-3.6A)
 1.00A 3axzA-2yquA:
undetectable		 3axzA-2yquA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 ILE A 397
ALA A 417
LEU A 441
ALA A 430
 None
 0.90A 3hrdA-2yquA:
2.1
3hrdB-2yquA:
3.0		 3hrdA-2yquA:
25.35
3hrdB-2yquA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 GLY A   8
VAL A 286
GLY A 301
ARG A  42
ILE A 300
 FAD  A1601 (-3.3A)
None
FAD  A1601 (-3.3A)
FAD  A1601 (-3.9A)
None
 1.18A 3k13A-2yquA:
undetectable		 3k13A-2yquA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 GLY A 275
ALA A 274
ILE A 133
VAL A 119
ILE A 297
 None
 1.01A 3s43B-2yquA:
undetectable		 3s43B-2yquA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 LEU A  98
ALA A  17
GLY A 317
ILE A 318
 None
 0.87A 3spkB-2yquA:
undetectable		 3spkB-2yquA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 LEU A  98
ILE A  18
GLY A  13
ILE A 318
ALA A 319
 None
 1.03A 3uwlB-2yquA:
undetectable		 3uwlB-2yquA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 LEU A  36
LEU A   4
LEU A   5
ALA A  16
ALA A  20
 None
 1.09A 3vw7A-2yquA:
undetectable		 3vw7A-2yquA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97E-2yquA:
2.4		 4a97E-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97C-2yquA:
2.3		 4a97C-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 8 TYR A 265
VAL A 303
ILE A 284
GLU A  31
 FAD  A1601 (-4.8A)
None
None
FAD  A1601 (-2.7A)
 0.87A 4a97G-2yquA:
undetectable		 4a97G-2yquA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		3 / 3 LEU A 208
GLU A 209
SER A 211
 None
 0.83A 4ccqA-2yquA:
24.5		 4ccqA-2yquA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		3 / 3 PRO A 307
VAL A 331
HIS A 330
 None
 0.85A 4pevC-2yquA:
undetectable		 4pevC-2yquA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 ILE A 318
GLY A 317
ALA A 136
HIS A 323
VAL A 321
 None
None
FAD  A1601 (-4.7A)
None
None
 1.09A 4rvdA-2yquA:
2.4		 4rvdA-2yquA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 8 ALA A 136
VAL A   6
GLY A  12
ALA A 313
GLY A 317
 FAD  A1601 (-4.7A)
None
FAD  A1601 (-3.6A)
FAD  A1601 (-3.6A)
None
 1.26A 4zjzB-2yquA:
undetectable		 4zjzB-2yquA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 6 VAL A 331
TYR A 333
VAL A 286
HIS A 289
 None
 1.00A 5eclA-2yquA:
undetectable		 5eclA-2yquA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 4 VAL A 294
GLU A 116
GLY A 275
LEU A 276
 None
 1.38A 5g5gC-2yquA:
undetectable		 5g5gC-2yquA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 5 GLY A 282
ASP A 279
ARG A 283
MET A 199
 None
 1.23A 5gwkA-2yquA:
2.5		 5gwkA-2yquA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 ILE A 336
ILE A 284
ALA A 299
LEU A 290
ALA A 320
 None
 1.38A 5zjiB-2yquA:
undetectable		 5zjiB-2yquA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 12 ILE A 297
ALA A 299
ILE A   7
ALA A 320
LEU A 271
 None
 0.94A 6a5zD-2yquA:
undetectable		 6a5zD-2yquA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		4 / 7 LEU A 134
PHE A  99
LEU A   4
ALA A  20
 None
 0.78A 6a7jA-2yquA:
undetectable		 6a7jA-2yquA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT
(Thermus
thermophilus) 		5 / 10 ALA A 390
GLY A 366
PHE A 385
VAL A 388
ASP A 207
 None
 1.38A 6clxB-2yquA:
3.5		 6clxB-2yquA:
24.84