SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 8 ASP A 142
ILE A  53
HIS A 112
HIS A  18
None
0.99A 1ei6D-2yr0A:
undetectable
1ei6D-2yr0A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 11 LEU A  57
GLU A  40
ILE A  65
VAL A  48
PHE A  77
None
1.30A 1gx9A-2yr0A:
undetectable
1gx9A-2yr0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A 116
LEU A 113
GLY A  47
MET A  73
GLN A 220
None
1.44A 1p93A-2yr0A:
undetectable
1p93A-2yr0A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A  34
LEU A 138
LEU A 257
ARG A 261
ALA A  31
None
1.24A 1pbcA-2yr0A:
undetectable
1pbcA-2yr0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBF_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 9 VAL A  34
LEU A 138
LEU A 257
ARG A 261
ALA A  31
None
1.30A 1pbfA-2yr0A:
2.4
1pbfA-2yr0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
None
0.45A 2gluA-2yr0A:
18.1
2gluA-2yr0A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A  46
GLY A  47
GLY A  49
ASP A  70
LEU A 113
None
0.65A 2nxeB-2yr0A:
13.0
2nxeB-2yr0A:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
11 / 12 GLY A  47
GLY A  49
ILE A  53
LEU A  67
ALA A  69
ASP A  70
ALA A  95
VAL A 111
HIS A 112
LEU A 113
LEU A 116
None
0.36A 2yqzA-2yr0A:
37.5
2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 12 GLY A  47
ILE A 109
ALA A  69
ASP A  70
LEU A 113
LEU A 116
None
1.29A 2yqzA-2yr0A:
37.5
2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A  67
ALA A  69
ASP A  70
ALA A  95
ARG A  96
None
0.81A 2yqzA-2yr0A:
37.5
2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 5 GLU A  45
ARG A  52
ASP A  68
ASP A  94
None
0.79A 2yqzA-2yr0A:
37.5
2yqzA-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
12 / 12 GLY A  47
GLY A  49
ILE A  53
LEU A  67
ALA A  69
ASP A  70
ALA A  95
VAL A 111
HIS A 112
LEU A 113
LEU A 116
VAL A 117
None
0.42A 2yqzB-2yr0A:
36.8
2yqzB-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
7 / 12 GLY A  47
ILE A 109
ALA A  69
ASP A  70
LEU A 113
LEU A 116
VAL A 117
None
1.29A 2yqzB-2yr0A:
36.8
2yqzB-2yr0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 5 GLU A  45
ARG A  52
ASP A  68
ASP A  94
None
0.78A 2yqzB-2yr0A:
36.8
2yqzB-2yr0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
3 / 3 LEU A 100
VAL A 123
ARG A 129
None
0.73A 3b0wB-2yr0A:
undetectable
3b0wB-2yr0A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A  46
GLY A  47
ASP A  68
ASP A  70
LEU A 113
None
0.64A 3cjtC-2yr0A:
13.8
3cjtC-2yr0A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A  46
GLY A  47
GLY A  49
ASP A  70
LEU A 113
None
0.68A 3cjtG-2yr0A:
13.2
3cjtG-2yr0A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 LEU A  46
GLY A  47
GLY A  49
ASP A  70
LEU A 113
None
0.67A 3cjtO-2yr0A:
13.8
3cjtO-2yr0A:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 11 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.37A 3g88A-2yr0A:
14.7
3g88A-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 11 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.37A 3g88B-2yr0A:
14.7
3g88B-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 12 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.37A 3g89A-2yr0A:
14.7
3g89A-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 11 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.37A 3g89B-2yr0A:
14.7
3g89B-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 12 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.36A 3g8bA-2yr0A:
14.6
3g8bA-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 12 GLY A  47
GLY A  49
ASP A  68
ALA A  69
ALA A  95
ARG A  52
None
1.37A 3g8bB-2yr0A:
13.3
3g8bB-2yr0A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
6 / 12 GLU A  45
GLY A  47
GLY A  49
ASP A  70
ASP A  94
ALA A  95
None
1.16A 3gryA-2yr0A:
12.0
3gryA-2yr0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 GLY A  47
GLY A  49
GLY A  51
ASP A  94
LEU A 113
None
0.99A 3ihtA-2yr0A:
10.3
3ihtA-2yr0A:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gB-2yr0A:
undetectable
3j6gB-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gD-2yr0A:
undetectable
3j6gD-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gF-2yr0A:
undetectable
3j6gF-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gH-2yr0A:
undetectable
3j6gH-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gJ-2yr0A:
undetectable
3j6gJ-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gL-2yr0A:
undetectable
3j6gL-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gN-2yr0A:
undetectable
3j6gN-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gP-2yr0A:
undetectable
3j6gP-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 VAL A 251
SER A 147
GLN A 220
ARG A 202
LEU A 211
None
1.41A 3j6gR-2yr0A:
undetectable
3j6gR-2yr0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 GLU A  45
GLY A  47
GLY A  49
THR A  50
ASP A  94
None
0.92A 3sglA-2yr0A:
11.4
3sglA-2yr0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 11 HIS A  18
ILE A  53
LEU A  44
ASP A  68
GLY A  49
None
1.40A 4foxF-2yr0A:
undetectable
4foxF-2yr0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ALA A  54
GLY A  47
GLY A  49
PHE A  77
LEU A 100
None
1.01A 4n49A-2yr0A:
8.0
4n49A-2yr0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ALA A  54
GLN A  89
ILE A  81
LEU A  74
GLY A  49
None
1.23A 4r38B-2yr0A:
undetectable
4r38B-2yr0A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ALA A  54
GLN A  89
ILE A  81
LEU A  74
GLY A  49
None
1.20A 4r38C-2yr0A:
undetectable
4r38C-2yr0A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ALA A  54
GLN A  89
ILE A  81
LEU A  74
GLY A  49
None
1.20A 4r38D-2yr0A:
undetectable
4r38D-2yr0A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 VAL A  91
ILE A  98
VAL A 108
VAL A 110
LEU A 113
None
1.13A 4y0qA-2yr0A:
undetectable
4y0qA-2yr0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 7 VAL A  90
ALA A  66
GLY A  49
ARG A  78
None
0.89A 5fpdB-2yr0A:
undetectable
5fpdB-2yr0A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 6 GLY A 140
ASP A  68
ILE A  65
TYR A  64
None
1.14A 5iwuA-2yr0A:
undetectable
5iwuA-2yr0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ALA A  17
GLY A  51
ALA A  66
ALA A  54
TYR A  64
None
1.19A 5n5dA-2yr0A:
15.2
5n5dA-2yr0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
3 / 3 GLU A 163
HIS A 227
VAL A 226
None
0.87A 5trqB-2yr0A:
undetectable
5trqB-2yr0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 5 LEU A 116
LEU A 113
MET A  73
GLN A 220
None
1.31A 5uc3A-2yr0A:
undetectable
5uc3A-2yr0A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 GLY A  47
ASP A  68
ASP A  70
ALA A  95
LEU A 113
None
0.60A 6bq4A-2yr0A:
12.0
6bq4A-2yr0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 GLY A  47
ASP A  68
ASP A  70
ALA A  95
LEU A 113
None
0.61A 6bq4B-2yr0A:
12.4
6bq4B-2yr0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 ILE A  65
LEU A  57
GLY A 107
ILE A  98
LEU A  46
None
1.03A 6dwnC-2yr0A:
undetectable
6dwnC-2yr0A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
3 / 3 PHE A 249
ARG A 202
ALA A 144
None
0.84A 6ecfB-2yr0A:
3.3
6ecfB-2yr0A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
3 / 3 TRP A 198
GLU A 252
GLU A 194
None
0.62A 6fhwA-2yr0A:
undetectable
6fhwA-2yr0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_B_ACRB801_2
(GLUCOAMYLASE P)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
4 / 4 TRP A 198
GLU A 252
GLU A 194
LEU A 256
None
1.36A 6fhwB-2yr0A:
undetectable
6fhwB-2yr0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 10 PHE A 165
ALA A 160
THR A 151
PHE A 218
VAL A 167
None
1.18A 6hu9C-2yr0A:
undetectable
6hu9C-2yr0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus)
5 / 12 PHE A 165
ALA A 160
THR A 151
PHE A 218
VAL A 167
None
1.17A 6hu9N-2yr0A:
undetectable
6hu9N-2yr0A:
20.00