SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		4 / 7 VAL A 131
ILE A 128
HIS A 147
GLU A  90
 None
 1.03A 1j96B-2yr1A:
9.2		 1j96B-2yr1A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		4 / 6 ASP A  54
GLU A 121
TYR A 124
ARG A  89
 None
 1.41A 1yc2A-2yr1A:
undetectable
1yc2B-2yr1A:
1.8
1yc2E-2yr1A:
0.7		 1yc2A-2yr1A:
23.78
1yc2B-2yr1A:
23.78
1yc2E-2yr1A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		3 / 3 VAL A  41
GLU A  37
GLU A  40
 None
 0.80A 2nv4A-2yr1A:
undetectable		 2nv4A-2yr1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		4 / 6 ARG A 167
ILE A 128
VAL A 144
LEU A 122
 None
 1.06A 4em2A-2yr1A:
undetectable		 4em2A-2yr1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 214
GLY A 238
GLY A 210
ALA A 207
ALA A 236
 None
 1.13A 4kicB-2yr1A:
2.3		 4kicB-2yr1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		5 / 10 ILE A  13
LEU A  48
ILE A 172
ALA A 225
ILE A   3
 None
 1.03A 5mvmD-2yr1A:
undetectable
5mvmE-2yr1A:
undetectable		 5mvmD-2yr1A:
16.14
5mvmE-2yr1A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 205
GLY A 223
ILE A   3
ILE A  15
ILE A 172
 None
 1.07A 6ebzB-2yr1A:
undetectable		 6ebzB-2yr1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 205
GLY A 223
ILE A   3
ILE A  15
ILE A 172
 None
 1.07A 6ebzC-2yr1A:
undetectable		 6ebzC-2yr1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2yr1 3-DEHYDROQUINATE
DEHYDRATASE
(Geobacillus
kaustophilus) 		5 / 11 THR A 205
GLY A 223
ILE A   3
ILE A  15
ILE A 172
 None
 1.05A 6gp2B-2yr1A:
undetectable		 6gp2B-2yr1A:
11.58