SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IJI_H_BEZH501_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF)	2yr3	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE (Homo sapiens)	4 / 7	ASN A 85 ALA A 11 VAL A 35 ARG A 36	None	1.14A	4ijiH-2yr3A: undetectable	4ijiH-2yr3A: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1Y_B_LOCB502_1 (TUBULIN BETA CHAIN)	2yr3	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE (Homo sapiens)	5 / 12	CYH A 92 ALA A 94 THR A 58 ALA A 64 ILE A 43	None	1.11A	4x1yB-2yr3A: undetectable	4x1yB-2yr3A: 12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CR1_A_T44A201_1 (TRANSTHYRETIN)	2yr3	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE (Homo sapiens)	4 / 5	LEU A 66 ALA A 64 LEU A 31 VAL A 35	None	1.11A	5cr1A-2yr3A: undetectable	5cr1A-2yr3A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_2 (TUBULIN BETA CHAIN)	2yr3	MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE (Homo sapiens)	5 / 12	CYH A 92 ALA A 94 THR A 58 ALA A 64 ILE A 43	None	1.25A	5xiwD-2yr3A: undetectable	5xiwD-2yr3A: 20.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4IJI_H_BEZH501_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN YIBF","2yr3","MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE","Homo sapiens",4,"ASN A  85;ALA A  11;VAL A  35;ARG A  36","None","1.14A","4ijiH-2yr3A:undetectable","4ijiH-2yr3A:19.91"],["4X1Y_B_LOCB502_1","TUBULIN BETA CHAIN","2yr3","MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE","Homo sapiens",5,"CYH A  92;ALA A  94;THR A  58;ALA A  64;ILE A  43","None","1.11A","4x1yB-2yr3A:undetectable","4x1yB-2yr3A:12.50"],["5CR1_A_T44A201_1","TRANSTHYRETIN","2yr3","MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE","Homo sapiens",4,"LEU A  66;ALA A  64;LEU A  31;VAL A  35","None","1.11A","5cr1A-2yr3A:undetectable","5cr1A-2yr3A:20.17"],["5XIW_D_LOCD503_2","TUBULIN BETA CHAIN","2yr3","MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE","Homo sapiens",5,"CYH A  92;ALA A  94;THR A  58;ALA A  64;ILE A  43","None","1.25A","5xiwD-2yr3A:undetectable","5xiwD-2yr3A:20.75"]]