SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 GLY A  67
TYR A  73
LEU A 669
ALA A 668
 FAD  A 801 (-3.4A)
None
None
None
 0.73A 1dmaA-2yr5A:
undetectable		 1dmaA-2yr5A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 4 THR A 202
LEU A 206
VAL A 209
LEU A 213
 None
 0.70A 1fbmD-2yr5A:
undetectable		 1fbmD-2yr5A:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 VAL A 367
LEU A  75
LEU A  72
ALA A 650
 None
 0.88A 1j8uA-2yr5A:
undetectable		 1j8uA-2yr5A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 ALA A  18
VAL A  21
TRP A 152
 None
 0.90A 1nt5A-2yr5A:
undetectable		 1nt5A-2yr5A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 ALA A  18
VAL A  21
TRP A 152
 None
 0.90A 1nt5B-2yr5A:
undetectable		 1nt5B-2yr5A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ILE A 110
ASP A 134
GLY A 133
LEU A 115
TYR A 137
 None
 1.08A 1rjdC-2yr5A:
undetectable		 1rjdC-2yr5A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 ALA A 123
ILE A 136
ILE A 520
ASP A 134
 None
 0.89A 1upfB-2yr5A:
undetectable		 1upfB-2yr5A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 10 LEU A 669
ALA A 691
PRO A  48
LEU A  78
ILE A 676
 None
 1.13A 1yi4A-2yr5A:
undetectable		 1yi4A-2yr5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 124
LEU A 115
ALA A 122
ARG A 351
THR A 482
 None
 1.36A 2aa6A-2yr5A:
undetectable		 2aa6A-2yr5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLU A  94
GLY A  63
ALA A 409
ALA A 650
 None
FAD  A 801 (-2.7A)
FAD  A 801 (-3.1A)
None
None
 1.16A 2bm9A-2yr5A:
3.3		 2bm9A-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.90A 2bm9A-2yr5A:
3.3		 2bm9A-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.97A 2bm9C-2yr5A:
undetectable		 2bm9C-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLU A  94
GLY A  63
ALA A 409
ALA A 650
 None
FAD  A 801 (-2.7A)
FAD  A 801 (-3.1A)
None
None
 1.18A 2bm9D-2yr5A:
3.0		 2bm9D-2yr5A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.86A 2br4A-2yr5A:
2.3		 2br4A-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.86A 2br4D-2yr5A:
undetectable		 2br4D-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.85A 2br4E-2yr5A:
undetectable		 2br4E-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 389
GLY A  63
TYR A  93
ALA A 409
ALA A 650
 None
FAD  A 801 (-3.1A)
None
None
None
 0.83A 2br4F-2yr5A:
3.2		 2br4F-2yr5A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 VAL A 343
GLU A 138
GLU A 345
 None
 0.73A 2nv4A-2yr5A:
undetectable		 2nv4A-2yr5A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 LEU A 206
MET A 327
MET A 328
LEU A 269
 None
 1.48A 2oz7A-2yr5A:
undetectable		 2oz7A-2yr5A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 MET A 327
LEU A 269
PRO A 232
GLY A 211
 None
 0.88A 2po5A-2yr5A:
undetectable		 2po5A-2yr5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 MET A 327
LEU A 269
PRO A 232
GLY A 211
 None
 0.92A 2po5B-2yr5A:
undetectable		 2po5B-2yr5A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 GLU A  74
LEU A  49
LEU A 150
HIS A 153
 None
 1.09A 2q0iA-2yr5A:
undetectable		 2q0iA-2yr5A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 5 SER A 653
HIS A 412
ARG A 119
SER A 651
 None
None
FAD  A 801 (-3.4A)
FAD  A 801 (-2.7A)
 1.15A 2qhfA-2yr5A:
0.0		 2qhfA-2yr5A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 TYR A 320
SER A 476
TYR A 536
SER A 535
 None
FAD  A 801 ( 3.7A)
SO4  A 903 ( 4.7A)
None
 0.99A 2v0zO-2yr5A:
undetectable		 2v0zO-2yr5A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 PRO A 232
LEU A 332
ARG A 329
 None
 0.80A 3aqiA-2yr5A:
undetectable		 3aqiA-2yr5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 PRO A 232
LEU A 332
ARG A 329
 None
 0.85A 3aqiB-2yr5A:
undetectable		 3aqiB-2yr5A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 PRO A 411
GLY A  65
GLY A  63
SER A 653
GLY A 118
 FAD  A 801 (-4.2A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.1A)
None
FAD  A 801 (-3.2A)
 1.07A 3axzA-2yr5A:
undetectable		 3axzA-2yr5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 11 LEU A 661
ALA A 155
PHE A 159
ALA A 158
PHE A 144
 FAD  A 801 (-3.9A)
None
None
None
FAD  A 801 (-4.3A)
 1.46A 3bszF-2yr5A:
undetectable		 3bszF-2yr5A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 10 ALA A 357
ALA A 409
ILE A 407
LEU A 675
TYR A 154
 None
 1.00A 3fl9A-2yr5A:
undetectable		 3fl9A-2yr5A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 640
ILE A 464
ARG A 463
LEU A 630
ARG A 633
 None
 1.34A 3ia4A-2yr5A:
undetectable		 3ia4A-2yr5A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 LEU A 657
GLY A 616
ALA A 474
ILE A 322
 None
FAD  A 801 (-3.8A)
None
None
 0.81A 3jusB-2yr5A:
undetectable		 3jusB-2yr5A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.92A 3ln1A-2yr5A:
undetectable		 3ln1A-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.92A 3ln1B-2yr5A:
undetectable		 3ln1B-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.92A 3ln1C-2yr5A:
undetectable		 3ln1C-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.91A 3ln1D-2yr5A:
undetectable		 3ln1D-2yr5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ILE A 676
LEU A  78
HIS A 153
ILE A  92
GLY A  68
 None
 1.08A 3ozwB-2yr5A:
3.6		 3ozwB-2yr5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 ILE A 261
VAL A 325
ARG A 329
 None
 0.65A 3p73A-2yr5A:
undetectable		 3p73A-2yr5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ARG A 119
GLY A  67
GLY A  65
LEU A  72
ALA A 650
 FAD  A 801 (-3.4A)
FAD  A 801 (-3.4A)
FAD  A 801 (-3.6A)
None
None
 1.25A 3sxjA-2yr5A:
undetectable		 3sxjA-2yr5A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ARG A 119
GLY A  67
GLY A  65
LEU A  72
ALA A 650
 FAD  A 801 (-3.4A)
FAD  A 801 (-3.4A)
FAD  A 801 (-3.6A)
None
None
 1.25A 3sxjB-2yr5A:
undetectable		 3sxjB-2yr5A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 5 HIS A  33
SER A  36
SER A  40
VAL A  39
 None
 1.00A 4a99D-2yr5A:
10.4		 4a99D-2yr5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 ARG A 329
HIS A  33
LEU A 239
ASP A  35
 None
 1.22A 4cevA-2yr5A:
undetectable
4cevB-2yr5A:
undetectable		 4cevA-2yr5A:
18.36
4cevB-2yr5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 ASP A  35
ARG A 329
HIS A  33
LEU A 239
 None
 1.22A 4cevA-2yr5A:
undetectable
4cevC-2yr5A:
undetectable		 4cevA-2yr5A:
18.36
4cevC-2yr5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 ARG A 329
HIS A  33
LEU A 239
ASP A  35
 None
 1.23A 4cevD-2yr5A:
undetectable
4cevE-2yr5A:
3.4		 4cevD-2yr5A:
18.36
4cevE-2yr5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 ARG A 329
HIS A  33
LEU A 239
ASP A  35
 None
 1.24A 4cevE-2yr5A:
3.4
4cevF-2yr5A:
3.5		 4cevE-2yr5A:
18.36
4cevF-2yr5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 ASP A  96
VAL A 374
ASN A 611
 GOL  A 902 (-4.0A)
FAD  A 801 ( 4.1A)
GOL  A 902 ( 3.8A)
 0.79A 4lmnA-2yr5A:
undetectable		 4lmnA-2yr5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 PHE A 178
ASP A 185
SER A 200
TYR A 187
 None
 1.18A 4lv9A-2yr5A:
undetectable
4lv9B-2yr5A:
undetectable		 4lv9A-2yr5A:
20.95
4lv9B-2yr5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 TYR A 187
PHE A 178
ASP A 185
SER A 200
 None
 1.17A 4lv9A-2yr5A:
undetectable
4lv9B-2yr5A:
undetectable		 4lv9A-2yr5A:
20.95
4lv9B-2yr5A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 VAL A 605
LEU A 545
TRP A 589
ALA A 534
SER A 513
 None
 1.01A 4o1zB-2yr5A:
undetectable		 4o1zB-2yr5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 THR A 610
ARG A 546
PHE A 606
SER A 477
 None
SO4  A3001 (-3.7A)
None
None
 1.49A 4o4dA-2yr5A:
undetectable		 4o4dA-2yr5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 MET A 328
MET A 621
TYR A 264
 None
 1.32A 4p6xI-2yr5A:
undetectable		 4p6xI-2yr5A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 LEU A 286
PHE A 306
VAL A 208
THR A 202
TRP A 195
 None
 1.27A 4q15A-2yr5A:
undetectable		 4q15A-2yr5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 GLY A 270
TYR A 335
GLY A 659
PHE A 311
THR A 268
 None
GOL  A 901 ( 4.7A)
FAD  A 801 (-3.8A)
None
None
 1.24A 4zdyA-2yr5A:
undetectable		 4zdyA-2yr5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 THR A  81
HIS A 635
LEU A 687
 None
 0.82A 5axdC-2yr5A:
4.2		 5axdC-2yr5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 117
GLY A  67
GLY A  65
GLY A  63
GLU A 662
 None
FAD  A 801 (-3.4A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.1A)
None
 0.97A 5c0oH-2yr5A:
3.6		 5c0oH-2yr5A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 ALA A 377
HIS A 379
PRO A 449
LEU A 451
 None
 1.14A 5dzkF-2yr5A:
2.0
5dzkT-2yr5A:
undetectable		 5dzkF-2yr5A:
16.84
5dzkT-2yr5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 GLY A 270
TYR A 335
GLY A 659
PHE A 311
THR A 268
 None
GOL  A 901 ( 4.7A)
FAD  A 801 (-3.8A)
None
None
 1.24A 5eslA-2yr5A:
undetectable		 5eslA-2yr5A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 MET A 666
HIS A  33
GLY A 149
 None
 0.81A 5gwzB-2yr5A:
undetectable		 5gwzB-2yr5A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.97A 5jw1A-2yr5A:
undetectable		 5jw1A-2yr5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.98A 5jw1B-2yr5A:
undetectable		 5jw1B-2yr5A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.90A 5kirA-2yr5A:
undetectable		 5kirA-2yr5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 ALA A 236
VAL A 214
GLY A 211
ALA A 210
LEU A 206
 None
 0.88A 5kirB-2yr5A:
undetectable		 5kirB-2yr5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 THR A 613
PRO A 411
ASP A 652
 None
FAD  A 801 (-4.2A)
FAD  A 801 (-3.3A)
 0.73A 5l8dB-2yr5A:
undetectable		 5l8dB-2yr5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 11 ALA A 671
GLY A  67
GLY A  68
ALA A  71
TYR A 654
 None
FAD  A 801 (-3.4A)
None
None
None
 1.00A 5lf3K-2yr5A:
undetectable
5lf3L-2yr5A:
undetectable		 5lf3K-2yr5A:
14.72
5lf3L-2yr5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 11 ALA A 671
GLY A  67
GLY A  68
ALA A  71
TYR A 654
 None
FAD  A 801 (-3.4A)
None
None
None
 1.01A 5lf3Y-2yr5A:
undetectable
5lf3Z-2yr5A:
undetectable		 5lf3Y-2yr5A:
14.72
5lf3Z-2yr5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 ALA A 223
ALA A 272
ILE A 276
GLU A 275
 None
 0.68A 5mvmA-2yr5A:
undetectable
5mvmB-2yr5A:
undetectable		 5mvmA-2yr5A:
8.35
5mvmB-2yr5A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 THR A 613
PRO A 411
ASP A 652
 None
FAD  A 801 (-4.2A)
FAD  A 801 (-3.3A)
 0.73A 5mwuB-2yr5A:
undetectable		 5mwuB-2yr5A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 GLU A 372
ARG A 370
TYR A  93
 None
 0.47A 5trqB-2yr5A:
undetectable		 5trqB-2yr5A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 5 GLY A 658
ARG A 329
ASP A 652
GLN A 414
 None
None
FAD  A 801 (-3.3A)
FAD  A 801 ( 3.1A)
 1.43A 5ubbA-2yr5A:
undetectable		 5ubbA-2yr5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 GLN A 414
GLY A  65
GLY A 118
GLY A  67
GLY A  68
 FAD  A 801 ( 3.1A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.2A)
FAD  A 801 (-3.4A)
None
 1.00A 5wyqA-2yr5A:
undetectable		 5wyqA-2yr5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 PRO A 411
GLN A 414
GLY A  65
GLY A 118
GLY A  67
 FAD  A 801 (-4.2A)
FAD  A 801 ( 3.1A)
FAD  A 801 (-3.6A)
FAD  A 801 (-3.2A)
FAD  A 801 (-3.4A)
 0.91A 5wyqA-2yr5A:
undetectable		 5wyqA-2yr5A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 8 TYR A  57
ILE A  59
LEU A 675
LEU A  49
 None
 0.86A 5y7pE-2yr5A:
undetectable		 5y7pE-2yr5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 6 HIS A 442
TYR A 444
GLU A 401
GLN A 388
 None
 1.48A 6d8pA-2yr5A:
0.0		 6d8pA-2yr5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		3 / 3 GLY A 212
ASP A 231
ILE A 227
 None
 0.57A 6dgxB-2yr5A:
undetectable		 6dgxB-2yr5A:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		5 / 12 GLY A 270
TYR A 335
GLY A 659
PHE A 311
THR A 268
 None
GOL  A 901 ( 4.7A)
FAD  A 801 (-3.8A)
None
None
 1.21A 6e8qA-2yr5A:
undetectable		 6e8qA-2yr5A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 4 LEU A 332
ASP A  35
PRO A  34
ARG A 329
 None
 1.42A 6fgdA-2yr5A:
3.6		 6fgdA-2yr5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE
(Pseudomonas
sp.
P-501) 		4 / 7 ASP A  89
ARG A  58
TYR A 403
GLU A 401
 None
 1.22A 6mn5B-2yr5A:
undetectable		 6mn5B-2yr5A:
7.44