SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		6 / 12 GLY A 238
ALA A 271
ILE A 334
GLY A 327
ILE A 325
ILE A 236
 None
 1.44A 1muiB-2yrfA:
undetectable		 1muiB-2yrfA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 9 ILE A  98
SER A 101
GLU A 105
ARG A 241
ASP A 278
 None
 1.37A 1nb9A-2yrfA:
undetectable		 1nb9A-2yrfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 ILE A 242
PHE A 277
MET A 335
THR A 336
 None
 0.84A 2einA-2yrfA:
undetectable
2einJ-2yrfA:
undetectable		 2einA-2yrfA:
20.95
2einJ-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 10 ASP A 135
LEU A 274
THR A 138
ILE A 189
GLY A 238
 None
 1.29A 2v0mA-2yrfA:
undetectable		 2v0mA-2yrfA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 7 ILE A 242
PHE A 277
MET A 335
THR A 336
 None
 1.01A 3ag2N-2yrfA:
undetectable
3ag2W-2yrfA:
undetectable		 3ag2N-2yrfA:
20.95
3ag2W-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 7 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 1.05A 3ag2N-2yrfA:
undetectable
3ag2W-2yrfA:
undetectable		 3ag2N-2yrfA:
20.95
3ag2W-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 7 ILE A 242
PHE A 277
MET A 335
THR A 336
 None
 0.98A 3ag4N-2yrfA:
undetectable
3ag4W-2yrfA:
undetectable		 3ag4N-2yrfA:
20.95
3ag4W-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 11 ALA A 239
PHE A 317
ILE A  56
PRO A  54
GLY A  52
 None
SO4  A 501 ( 4.7A)
None
None
SO4  A 501 (-4.2A)
 1.41A 3bpxA-2yrfA:
undetectable
3bpxB-2yrfA:
undetectable		 3bpxA-2yrfA:
17.13
3bpxB-2yrfA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 5 ASP A 154
ILE A 213
ILE A 156
GLY A 153
 None
 0.91A 3bufA-2yrfA:
undetectable		 3bufA-2yrfA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 6 VAL A  50
ILE A  58
ILE A  20
LEU A  21
 None
 0.80A 3hegA-2yrfA:
undetectable		 3hegA-2yrfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		3 / 3 ARG A 195
THR A 226
THR A 204
 None
 0.72A 3k2hB-2yrfA:
3.1		 3k2hB-2yrfA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 12 GLU A 296
LYS A 251
ASP A  43
ALA A  44
GLN A  24
 None
SO4  A 501 (-2.6A)
None
None
None
 1.35A 3nmuA-2yrfA:
undetectable
3nmuF-2yrfA:
2.3		 3nmuA-2yrfA:
22.71
3nmuF-2yrfA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 10 ILE A 328
ILE A 287
ILE A 289
ASN A 250
VAL A 270
 None
 1.44A 3ohtA-2yrfA:
undetectable
3ohtB-2yrfA:
undetectable		 3ohtA-2yrfA:
23.65
3ohtB-2yrfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 6 ILE A 159
ASN A 250
LEU A 257
ASP A 220
 None
 1.29A 3oi8A-2yrfA:
undetectable		 3oi8A-2yrfA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 10 ALA A  68
ILE A 131
LEU A 107
ILE A  45
ILE A  20
 None
 1.04A 3prsA-2yrfA:
undetectable		 3prsA-2yrfA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 SER A 168
ARG A 106
ILE A  58
GLU A 136
 None
 1.23A 4cx7A-2yrfA:
undetectable
4cx7B-2yrfA:
undetectable		 4cx7A-2yrfA:
20.89
4cx7B-2yrfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 SER A 168
ARG A 106
ILE A  58
GLU A 136
 None
 1.17A 4cx7C-2yrfA:
undetectable
4cx7D-2yrfA:
0.7		 4cx7C-2yrfA:
20.89
4cx7D-2yrfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 10 ALA A 263
ILE A 266
VAL A 235
ALA A 223
ALA A 224
 None
 0.95A 4lbgA-2yrfA:
3.2		 4lbgA-2yrfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 9 ALA A 263
ILE A 266
VAL A 235
ALA A 223
ALA A 224
 None
 1.03A 4lbgB-2yrfA:
4.2		 4lbgB-2yrfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 7 GLU A 291
GLU A 290
GLU A 296
ARG A  94
 None
None
None
SO4  A 501 (-3.1A)
 0.97A 4mi4B-2yrfA:
undetectable
4mi4C-2yrfA:
undetectable		 4mi4B-2yrfA:
22.10
4mi4C-2yrfA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 GLU A 291
GLU A 290
GLU A 296
ARG A  94
 None
None
None
SO4  A 501 (-3.1A)
 0.98A 4mj8B-2yrfA:
undetectable
4mj8C-2yrfA:
undetectable		 4mj8B-2yrfA:
19.83
4mj8C-2yrfA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 8 LYS A  69
ALA A  68
GLY A  63
LEU A  64
LEU A  83
 None
 1.48A 4po0A-2yrfA:
2.9		 4po0A-2yrfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		5 / 12 THR A 194
GLN A 199
ASP A 240
ALA A 249
ILE A 159
 None
SO4  A 501 (-4.7A)
SO4  A 501 ( 3.9A)
None
None
 1.36A 4rp9A-2yrfA:
undetectable		 4rp9A-2yrfA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 6 LEU A  64
LEU A 107
SER A 110
VAL A 117
 None
 1.17A 5a6iA-2yrfA:
undetectable		 5a6iA-2yrfA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 6 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.92A 5b1aN-2yrfA:
undetectable
5b1aW-2yrfA:
undetectable		 5b1aN-2yrfA:
20.95
5b1aW-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		6 / 12 ALA A 166
THR A  59
GLY A  52
GLY A  57
GLU A 296
LEU A  48
 None
None
SO4  A 501 (-4.2A)
None
None
None
 1.25A 5c0oG-2yrfA:
5.5		 5c0oG-2yrfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 7 ILE A 242
PHE A 277
MET A 335
THR A 336
 None
 0.92A 5iy5N-2yrfA:
undetectable
5iy5W-2yrfA:
undetectable		 5iy5N-2yrfA:
20.95
5iy5W-2yrfA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.90A 5zcoA-2yrfA:
undetectable
5zcoJ-2yrfA:
undetectable		 5zcoA-2yrfA:
20.95
5zcoJ-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE
(Bacillus
subtilis) 		4 / 8 ILE A 343
LEU A 346
PHE A 347
ARG A 241
 None
 0.95A 5zcqN-2yrfA:
undetectable
5zcqW-2yrfA:
undetectable		 5zcqN-2yrfA:
20.95
5zcqW-2yrfA:
11.53