SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2yro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 7 PHE A  99
PHE A  93
PHE A  71
VAL A  35
 None
 0.96A 1lh6A-2yroA:
undetectable		 1lh6A-2yroA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 5 PHE A  99
PHE A  93
PHE A  71
VAL A  35
 None
 0.95A 2lh6A-2yroA:
undetectable		 2lh6A-2yroA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  61
ASN A  63
ASN A  74
TRP A  81
 None
 0.68A 3galA-2yroA:
19.0		 3galA-2yroA:
37.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 6 HIS A  61
ASN A  63
ASN A  74
TRP A  81
 None
 0.60A 3galB-2yroA:
18.5		 3galB-2yroA:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2yro GALECTIN-8
(Homo
sapiens) 		5 / 12 GLY A  28
ILE A 132
ALA A  59
PHE A 126
HIS A 124
 None
 1.09A 4wh5A-2yroA:
undetectable		 4wh5A-2yroA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 5 PRO A  92
VAL A 114
GLY A 139
VAL A  39
 None
 1.09A 6ak3B-2yroA:
undetectable		 6ak3B-2yroA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 7 HIS A  61
ASN A  63
ASN A  74
TRP A  81
 None
 0.71A 6b8kA-2yroA:
20.0		 6b8kA-2yroA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 2yro GALECTIN-8
(Homo
sapiens) 		4 / 8 ASN A  63
ASN A  74
TRP A  81
GLU A  84
 None
 0.84A 6b94A-2yroA:
16.8		 6b94A-2yroA:
35.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B94_A_W9TA201_0
(GALECTIN-1)		 2yro GALECTIN-8
(Homo
sapiens) 		5 / 8 HIS A  61
ASN A  63
ASN A  74
TRP A  81
ARG A  86
 None
 0.76A 6b94A-2yroA:
16.8		 6b94A-2yroA:
35.71